Polymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause

Polymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause

Author Souza, Marilene Alicia Google Scholar
Fonseca, Angela Maggio Google Scholar
Bagnoli, Vicente R. Google Scholar
Barros, Nestor de Google Scholar
Franzolin, Solange O. B. Google Scholar
Carvalho, Katia C. Google Scholar
Soares-, Jose Maria Autor UNIFESP Google Scholar
Baracat, Edmund C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The association of genetic polymorphism in the estrogen receptor alpha (ER alpha) gene and risk for diseases including breast cancer (BC) has been the subject of great interest.Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ER alpha gene and the correlation between them and the known risk factors for breast cancer.Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index.Results: the allelic and genotypic frequencies for ER alpha-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. the most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%).Conclusion: Allelic and genotypic distribution similar to literature. the risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.
Keywords Breast neoplasms
estrogen receptors
genetic polymorphism
risk factors
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2009/54563-0
Date 2013-08-01
Published in Gynecological Endocrinology. New York: Informa Healthcare, v. 29, n. 8, p. 771-774, 2013.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 771-774
Origin http://dx.doi.org/10.3109/09513590.2013.801438
Access rights Closed access
Type Article
Web of Science ID WOS:000321211400009
URI http://repositorio.unifesp.br/handle/11600/36638

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