Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance

Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance

Autor Rodrigues Danzi Salvia, Ana Carolina Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Pellegrini Braga, Josefina Aparecida Autor UNIFESP Google Scholar
Alves Pereira, Daniel Freitas Google Scholar
Brighenti, Fernanda Lourencao Google Scholar
Koga-Ito, C. Y. Google Scholar
Instituição Univ Estadual Paulista UNESP
Universidade Federal de São Paulo (UNIFESP)
Resumo BackgroundThe aim of this study was to evaluate the frequency of Candida species and presence of lesions in the oral cavity of patients with sickle cell anemia (SS).MethodsThe study included 30 patients diagnosed with sickle cell anemia and taking hydroxyurea for at least 90days (SS/HU+); and 39 patients with sickle cell anemia and without hydroxyurea therapy (SS/HU-). Two control groups were constituted by healthy individuals matched to the test groups in age, gender, and oral conditions (C/HU+ for SS/HU+ and C/HU- for SS/HU-). Oral clinical examination and anamnesis were performed. Yeasts were collected by oral rinses and identified by API system. Antifungal susceptibility evaluation was performed according to the CLSI methodology. Data obtained for microorganisms counts were compared by Student's t test (SS/HU+ vs. C/HU+ and SS/HU- vs. C/HU-) using MINITAB for Windows 1.4. Significance level was set at 5%.ResultsNo oral candidosis lesions were detected. Significant differences in yeasts counts were observed between SS/HU- group and the respective control, but there were no differences between SS/HU+ and C/HU+. Candida albicans was the most prevalent species in all groups. Candida famata was observed both in SS and control groups. Candida dubliniensis, Candida glabrata, Candida krusei, Candida tropicalis, Candida pelliculosa, and Candida parapsilosis were observed only in SS groups. Most strains were susceptible to all antifungal agents.ConclusionHydroxyurea therapy seems to decrease candidal counts and resistance rate in sickle cell anemia patients. However, further studies should be conducted in the future to confirm this finding. Hydroxyurea therapy in sickle cell anemia patients maintains fungal species balance in oral cavity.
Assunto antifungals
oral cavity
sickle cell anemia
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 2009/50028-3
FAPESP: 2008/56484-8
Data 2013-08-01
Publicado em Journal of Oral Pathology & Medicine. Hoboken: Wiley-Blackwell, v. 42, n. 7, p. 570-575, 2013.
ISSN 0904-2512 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 570-575
Fonte http://dx.doi.org/10.1111/jop.12029
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000329226600010
URI http://repositorio.unifesp.br/handle/11600/36625

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