Substantia nigra echogenicity is correlated with nigrostriatal impairment in Machado-Joseph disease

Substantia nigra echogenicity is correlated with nigrostriatal impairment in Machado-Joseph disease

Author Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Bor-Seng-Shu, Edson Google Scholar
Felicio, Andre C. Autor UNIFESP Google Scholar
Braga-Neto, Pedro Autor UNIFESP Google Scholar
Hoexter, Marcelo Q. Autor UNIFESP Google Scholar
Teixeira, Manoel Jacobsen Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background: Several studies have demonstrated increased substantia nigra (SN) echogenicity in Parkinson's disease (PD) and Machado-Joseph disease (MJD). Pathological substrate of PD is characterized by dopaminergic nigrostriatal cell loss, also found in MJD. Also, SN hyperechogenicity might be associated with nigrostriatal dysfunction in PD, when comparing dopamine transporter binding with SN echogenicity. the present study aimed to correlate the SN echogenic size and striatal dopamine transporter density in MJD patients.Methods: We performed TCS in 30 subjects and SPEC T with [Tc-99m]-TRODAT-1 in 18 subjects with MJD. Fifteen healthy subjects matched for age and gender formed a control group. TCS and [Tc-99m]-TRODAT-1 SPECT findings from both MJD patients and control subjects were compared.Results: There were no differences regarding age (p = 0358) or gender (p = 0.566) between groups (MJD versus control group). Mean DAT binding potentials and SN echogenicity were significantly different between groups. There was a significant negative correlation with regard to the SN echogenic size and the ipsilateral striatal TRODAT-1 uptake: the higher the SN echogenicity, the lower the DAT uptake in the ipsilateral cerebral hemisphere.Conclusion: Increase in SN echogenic size likely correlates with presynaptic dopaminergic nigrostriatal dysfunction in MJD, suggesting a concurrent in vivo pathophysiological mechanism. (c) 2013 Elsevier B.V. All rights reserved.
Keywords Transcranial sonography
Dopamine transporter
SPECT with [Tc-99m]-TRODAT-1
Dopaminergic dysfunction
Machado-Joseph disease
Language English
Date 2013-08-01
Published in Parkinsonism & Related Disorders. Oxford: Elsevier B.V., v. 19, n. 8, p. 742-745, 2013.
ISSN 1353-8020 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 742-745
Access rights Closed access
Type Article
Web of Science ID WOS:000321482100006

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