Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-alpha. Prospective Clinical Trial

Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-alpha. Prospective Clinical Trial

Autor Viana, Elaine Cristina Google Scholar
Araujo-Dasilio, Karine L. Google Scholar
Soares Miguel, Gustavo Peixoto Google Scholar
Bressan, Josefina Google Scholar
Lemos, Elenice Moreira Google Scholar
Moyses, Margareth Ribeiro Google Scholar
Abreu, Glaucia Rodrigues de Google Scholar
Moreira Coutinho de Azevedo, Joao Luiz Autor UNIFESP Google Scholar
Carvalho, Perseu Seixas Google Scholar
Passos-Bueno, Maria Rita S. Google Scholar
Valle Errera, Flavia Imbroisi Google Scholar
Bissoli, Nazare Souza Google Scholar
Instituição Univ Fed Espirito Santo
Universidade Federal de Viçosa (UFV)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
EMESCAM Coll Helth Sci
Univ Vila Velha
Resumo Due to the association between the quantity of adipose tissue and concentrations of interleukin-6 (IL-6) and tumor necrosis factor (TNF-alpha), this work aimed to assess the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) procedures on serum IL-6 and TNF-alpha concentrations.This study evaluated serum IL-6 and TNF-alpha levels, as well as routine anthropometric and biochemical values, before and 1 year post-bariatric surgery. Fifty percent of patients (n = 24) underwent RYGB, and 50 % (n = 24) underwent SG. Prior to bariatric surgery, IL-6 and TNF-alpha mRNA expression levels in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were investigated in obese women.There was a significant reduction (p < 0.05) in all anthropometric and routine biochemical measurements in patients in the RYGB and SG groups 1 year post-surgery. the serum concentrations of IL-6 and TNF-alpha were reduced following surgery in both groups (p < 0.05). No differences in the relative expression levels of IL-6 and TNF-alpha were found between SAT and VAT prior to bariatric surgery.RYGB and SG procedures demonstrated a similar impact on adipokine levels in women 1 year post-surgery. Both techniques may improve the course of chronic diseases and the state of inflammation associated with obesity.
Assunto IL-6
TNF-alpha
Bariatric surgery
Weight loss
Roux-en-Y gastric bypass
Sleeve gastrectomy
Idioma Inglês
Data 2013-08-01
Publicado em Obesity Surgery. New York: Springer, v. 23, n. 8, p. 1252-1261, 2013.
ISSN 0960-8923 (Sherpa/Romeo, fator de impacto)
Editor Springer
Extensão 1252-1261
Fonte http://dx.doi.org/10.1007/s11695-013-0894-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000321389200798
URI http://repositorio.unifesp.br/handle/11600/36591

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