hTERT and TP53 deregulation in intestinal-type gastric carcinogenesis in non-human primates

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dc.contributor.author Leal, Mariana Ferreira [UNIFESP]
dc.contributor.author Calcagno, Danielle Queiroz [UNIFESP]
dc.contributor.author Khayat, Andre Salim
dc.contributor.author Raiol Silva, Tanielly Cristina
dc.contributor.author Pereira Carneiro Muniz, Jose Augusto
dc.contributor.author Assumpcao, Paulo Pimentel
dc.contributor.author Cardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.author Burbano, Rommel Rodriguez
dc.date.accessioned 2016-01-24T14:32:03Z
dc.date.available 2016-01-24T14:32:03Z
dc.date.issued 2013-08-01
dc.identifier http://dx.doi.org/10.1007/s10238-012-0195-4
dc.identifier.citation Clinical and Experimental Medicine. Milan: Springer-verlag Italia Srl, v. 13, n. 3, p. 221-224, 2013.
dc.identifier.issn 1591-8890
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36584
dc.description.abstract Despite the high incidence, the molecular events involved in intestinal-type gastric carcinogenesis remains unclear. We previously established an intestinal-type gastric carcinogenesis model in Cebus apella, a New World monkey. in the present study, we evaluated hTERT and TP53 mRNA expression, as well as their protein immunoreactivity, in normal mucosa, non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, and intestinal-type gastric cancer samples of non-human primates treated with N-methyl-nitrosourea. in addition, we evaluated the number of TP53 copies in these samples. Although hTERT immunoreactivity was only detected in gastric cancer, a continuous increase of hTERT mRNA expression was observed from non-atrophic gastritis to gastric tumors. No sample presented p53 immunoreactivity. However, we also observed a continuous decrease of TP53 mRNA expression during the sequential steps of gastric carcinogenesis. Moreover, loss of TP53 copies was observed in intestinal metaplasia and gastric cancer samples. Our study highlights that hTERT and TP53 have a key role in intestinal-type gastric cancer initiation. en
dc.format.extent 221-224
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Clinical and Experimental Medicine
dc.rights Acesso restrito
dc.subject hTERT en
dc.subject TP53 en
dc.subject Gastric carcinogenesis en
dc.subject Non-human primates en
dc.subject Precancerous lesions en
dc.subject Animal model en
dc.title hTERT and TP53 deregulation in intestinal-type gastric carcinogenesis in non-human primates en
dc.type Carta
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Fed Univ Para
dc.contributor.institution Minist Saude
dc.description.affiliation Universidade Federal de São Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliation Fed Univ Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66059 Belem, Para, Brazil
dc.description.affiliation Minist Saude, Ctr Nacl Primatas, Ananindeua, PA, Brazil
dc.description.affiliation Fed Univ Para, Hosp Univ Joao de Barros Barreto, Unidade Alta Complexidade Oncol, BR-66059 Belem, Para, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1007/s10238-012-0195-4
dc.description.source Web of Science
dc.identifier.wos WOS:000322677400009



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