Progression of diffuse esophageal spasm to achalasia: incidence and predictive factors

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dc.contributor.author Fontes, L. H. S. [UNIFESP]
dc.contributor.author Herbella, F. A. M. [UNIFESP]
dc.contributor.author Rodriguez, T. N.
dc.contributor.author Trivino, T. [UNIFESP]
dc.contributor.author Farah, J. F. M. [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:59Z
dc.date.available 2016-01-24T14:31:59Z
dc.date.issued 2013-07-01
dc.identifier http://dx.doi.org/10.1111/j.1442-2050.2012.01377.x
dc.identifier.citation Diseases of the Esophagus. Hoboken: Wiley-Blackwell, v. 26, n. 5, p. 470-474, 2013.
dc.identifier.issn 1120-8694
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36523
dc.description.abstract The progression of certain primary esophageal motor disorders to achalasia has been documented; however, the true incidence of this decay is still elusive. This study aims to evaluate: (i) the incidence of the progression of diffuse esophageal spasm to achalasia, and (ii) predictive factors to this progression. Thirty-five patients (mean age 53 years, 80% females) with a manometric picture of diffuse esophageal spasm were followed for at least 1 year. Patients with gastroesophageal reflux disease confirmed by pH monitoring or systemic diseases that may affect esophageal motility were excluded. Esophageal manometry was repeated in all patients. Five (14%) of the patients progressed to achalasia at a mean follow-up of 2.1 (range 1-4) years. Demographic characteristics were not predictive of transition to achalasia, while dysphagia (P= 0.005) as the main symptom and the wave amplitude of simultaneous waves less than 50mmHg (P= 0.003) were statistically significant. in conclusion, the transition of diffuse esophageal spasm to achalasia is not frequent at a 2-year follow-up. Dysphagia and simultaneous waves with low amplitude are predictive factors for this degeneration. en
dc.description.sponsorship Department of Surgery of the Federal University of São Paulo
dc.description.sponsorship Public Servants State Hospital of the São Paulo
dc.format.extent 470-474
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Diseases of the Esophagus
dc.rights Acesso restrito
dc.subject achalasia en
dc.subject diffuse esophageal spasm en
dc.subject disease progression en
dc.subject manometry en
dc.title Progression of diffuse esophageal spasm to achalasia: incidence and predictive factors en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Publ Servants State Hosp
dc.description.affiliation Universidade Federal de São Paulo, Dept Surg, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Gastroenterol, BR-05403000 São Paulo, Brazil
dc.description.affiliation Publ Servants State Hosp, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Surg, Escola Paulista Med, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1442-2050.2012.01377.x
dc.description.source Web of Science
dc.identifier.wos WOS:000328932400005



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