Safety of lumbar puncture in patients with cerebral venous thrombosis

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dc.contributor.author Canhao, P.
dc.contributor.author Abreu, L. F.
dc.contributor.author Ferro, J. M.
dc.contributor.author Stam, J.
dc.contributor.author Bousser, M. G.
dc.contributor.author Barinagarrementeria, F.
dc.contributor.author Fukujima, M. M. [UNIFESP]
dc.contributor.author ISCVT Investigators
dc.date.accessioned 2016-01-24T14:31:58Z
dc.date.available 2016-01-24T14:31:58Z
dc.date.issued 2013-07-01
dc.identifier http://dx.doi.org/10.1111/ene.12136
dc.identifier.citation European Journal of Neurology. Hoboken: Wiley-Blackwell, v. 20, n. 7, p. 1075-1080, 2013.
dc.identifier.issn 1351-5101
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36520
dc.description.abstract Background and purpose Lumbar puncture (LP) may precipitate cerebral venous thrombosis (CVT), but it is unclear if LP is deleterious in patients with CVT. We aimed to assess the safety of LP in the International Study on Cerebral Veins and Dural Sinus Thrombosis prospective cohort. Methods in 624 patients with CVT, we compared the prognosis of patients submitted or not to LP. the primary outcome was death or dependency at 6months', as evaluated by the modified Rankin Scale (mRS; mRS=3-6, with adjustment for variables associated with poor prognosis); secondary outcomes were: worsening after admission'; acute death'; and complete recovery at 6months' (mRS=0-1). We analyzed the same outcomes in subgroups of patients with brain lesions on the admission computer tomography/magnetic resonance imaging. Results LP was performed in 224 patients (35.9%). There was no difference in frequency of death or dependency at 6months' between patients with or without LP [13.4% vs. 14.4%; odds ratio (OR)=0.9, 95% confidence interval (CI) 0.6-1.5; P=0.739]. LP was not associated with worsening after hospitalization' [21.5% vs. 23.5%; OR=0.9, 95% CI 0.6-1.3; P=0.577], acute death' [3.6% vs. 3.3%; OR=1.1, 95% CI 0.5-2.7; P=0.844] or complete recovery' [79.9% vs. 76.6%; OR=1.2, 95% CI 0.8-1.7; P=0.484]. in the subgroups of patients with brain lesions, the prognoses were not different between patients submitted or not to LP. Conclusion LP was not associated with the functional outcome of patients with CVT, suggesting that LP was not harmful in these patients. These results should not be generalized to patients with large brain lesions and risk of herniation where LP is contraindicated. en
dc.description.sponsorship PRAXIS grant from the Fundacao para a Ciencia e Tecnologia
dc.format.extent 1075-1080
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof European Journal of Neurology
dc.rights Acesso restrito
dc.subject cerebral venous thrombosis en
dc.subject lumbar puncture en
dc.subject prognosis en
dc.subject sinus thrombosis en
dc.subject vein thrombosis en
dc.subject venous thrombosis en
dc.title Safety of lumbar puncture in patients with cerebral venous thrombosis en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Hosp Santa Maria
dc.contributor.institution Univ Amsterdam
dc.contributor.institution Hop Lariboisiere
dc.contributor.institution Inst Nacl Neurol & Neurocirurgia
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Hosp Santa Maria, Dept Neurosci, P-1649035 Lisbon, Portugal
dc.description.affiliation Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands
dc.description.affiliation Hop Lariboisiere, Dept Neurol, F-75475 Paris, France
dc.description.affiliation Inst Nacl Neurol & Neurocirurgia, Dept Neurol, Mexico City, DF, Mexico
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.sponsorshipID PRAXIS grant from the Fundacao para a Ciencia e Tecnologia: C/SAU/10248/1998
dc.identifier.doi 10.1111/ene.12136
dc.description.source Web of Science
dc.identifier.wos WOS:000320131400016



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