Additive effects of non-invasive ventilation to hyperoxia on cerebral oxygenation in COPD patients with exercise-related O2 desaturation

Show simple item record

dc.contributor.author Rodrigues, Miguel K. [UNIFESP]
dc.contributor.author Oliveira, Mayron F. [UNIFESP]
dc.contributor.author Soares, Aline [UNIFESP]
dc.contributor.author Treptow, Erika [UNIFESP]
dc.contributor.author Alberto Neder, J. [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:58Z
dc.date.available 2016-01-24T14:31:58Z
dc.date.issued 2013-07-01
dc.identifier http://dx.doi.org/10.1111/cpf.12024
dc.identifier.citation Clinical Physiology and Functional Imaging. Hoboken: Wiley-Blackwell, v. 33, n. 4, p. 274-281, 2013.
dc.identifier.issn 1475-0961
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36519
dc.description.abstract Background It is currently unknown whether potential haemodynamic improvements induced by non-invasive ventilation (NIV) would positively impact upon cerebral oxygenation (COx) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). Objective To investigate the effects of NIV on exercise COx in COPD patients presenting with exercise-related O2 desaturation. Methods On a double-blind trial, 13 males (FEV1=48 center dot 8 +/- 15 center dot 1% predicted) were randomly assigned to NIV (16 cmH2O IPS and 5 cmH2O PEEP) plus HOx (FiO2= 0 center dot 4) or sham NIV (7 cmH2O IPS and 5 cmH2O PEEP to overcome breathing circuit resistance) plus HOx during ramp-incremental exercise performed on different days. Near-infrared spectroscopy and impedance cardiography assessed changes () in COx and cardiac output (QT), respectively. Results There were no significant between-intervention differences in peak work rate, ventilation and reported symptoms (0 center dot 05). Peripheral oxyhaemoglobin saturation remained above 98% throughout the tests. NIV+HOx was associated with larger increases in COx, QT and stroke volume at maximal and submaximal exercise (P<0 center dot 05). Increases in the area under the curve (to an iso-work rate) of COx under NIV+HOx were significantly (P<0 center dot 01) correlated with improvements in QT (r=0 center dot 82) and stroke volume (r=0 center dot 87). There was, however, no significant correlation between enhancement in these physiological responses with changes in peak work rate with NIV+HOx (0 center dot 05). Conclusions NIV added benefit to HOx in improving central haemodynamics and COx in O2 desaturators' with COPD. the clinical relevance of such beneficial effects on exercise tolerance, however, remains to be demonstrated. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 274-281
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Clinical Physiology and Functional Imaging
dc.rights Acesso restrito
dc.subject cerebral oxygenation en
dc.subject chronic obstructive pulmonary disease en
dc.subject exercise en
dc.subject lung physiology en
dc.subject near-infrared spectroscopy en
dc.subject non-invasive ventilation en
dc.title Additive effects of non-invasive ventilation to hyperoxia on cerebral oxygenation in COPD patients with exercise-related O2 desaturation en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Queens Univ
dc.description.affiliation Fed Univ São Paulo UNIFESP, Div Resp Dis, Dept Med, Pulm Funct & Clin Exercise Physiol Unit, São Paulo, Brazil
dc.description.affiliation Queens Univ, Div Resp & Crit Care Med, Dept Med, Lab Clin Exercise Physiol, Kingston, ON, Canada
dc.description.affiliation Queens Univ, Div Resp & Crit Care Med, Lab Clin Exercise Physiol, Dept Med, Kingston, ON KTL 2V6, Canada
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Div Resp Dis, Dept Med, Pulm Funct & Clin Exercise Physiol Unit, São Paulo, Brazil
dc.identifier.doi 10.1111/cpf.12024
dc.description.source Web of Science
dc.identifier.wos WOS:000319293100005



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account