Genome-wide association study identifies two susceptibility loci for osteosarcoma

Genome-wide association study identifies two susceptibility loci for osteosarcoma

Author Savage, Sharon A. Google Scholar
Mirabello, Lisa Google Scholar
Wang, Zhaoming Google Scholar
Gastier-Foster, Julie M. Google Scholar
Gorlick, Richard Google Scholar
Khanna, Chand Google Scholar
Flanagan, Adrienne M. Google Scholar
Tirabosco, Roberto Google Scholar
Andrulis, Irene L. Google Scholar
Wunder, Jay S. Google Scholar
Gokgoz, Nalan Google Scholar
Patino-Garcia, Ana Google Scholar
Sierrasesumaga, Luis Google Scholar
Lecanda, Fernando Google Scholar
Kurucu, Nilgun Google Scholar
Ilhan, Inci Ergurhan Google Scholar
Sari, Neriman Google Scholar
Serra, Massimo Google Scholar
Hattinger, Claudia Google Scholar
Picci, Piero Google Scholar
Spector, Logan G. Google Scholar
Barkauskas, Donald A. Google Scholar
Marina, Neyssa Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Petrilli, Antonio S. Autor UNIFESP Google Scholar
Amary, Maria Fernanda Google Scholar
Halai, Dina Google Scholar
Thomas, David M. Google Scholar
Douglass, Chester Google Scholar
Meltzer, Paul S. Google Scholar
Jacobs, Kevin Google Scholar
Chung, Charles C. Google Scholar
Berndt, Sonja I. Google Scholar
Purdue, Mark P. Google Scholar
Caporaso, Neil E. Google Scholar
Tucker, Margaret Google Scholar
Rothman, Nathaniel Google Scholar
Landi, Maria Teresa Google Scholar
Silverman, Debra T. Google Scholar
Kraft, Peter Google Scholar
Hunter, David J. Google Scholar
Malats, Nuria Google Scholar
Kogevinas, Manolis Google Scholar
Wacholder, Sholom Google Scholar
Troisi, Rebecca Google Scholar
Helman, Lee Google Scholar
Fraumeni, Joseph F. Google Scholar
Yeager, Meredith Google Scholar
Hoover, Robert N. Google Scholar
Chanock, Stephen J. Google Scholar
Institution NCI
Nationwide Childrens Hosp
Ohio State Univ
Childrens Hosp Montefiore
Royal Natl Orthopaed Hosp NHS Trust
Univ Toronto
Univ Navarra
AY Ankara Oncol Training & Res Hosp
Orthopaed Rizzoli Inst
Univ Minnesota
Univ So Calif
Stanford Univ
Lucile Packard Childrens Hosp
Universidade Federal de São Paulo (UNIFESP)
Univ Melbourne
Harvard Univ
Ctr Nacl Invest Oncol
Ctr Res Environm Epidemiol CREAL
IMIM Hosp Mar Med Res Inst
Network Biomed Res Ctr Epidemiol & Publ Hlth CIBE
Natl Sch Publ Hlth
Abstract Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 x 10(-9)) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 x 10(-8) and 2.9 x 10(-7), respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.
Language English
Sponsor Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health
Bone Cancer Research Trust UK
National Cancer Institute, US National Institutes of Health
WWWW (QuadW) Foundation to the Children's Oncology Group
Ontario Research Fund
Canadian Foundation for Innovation
Regione Emilia-Romagna
Royal National Orthopaedic Hospital Musculoskeletal Research Programme
National Institute for Health Research UCL Hospitals (UCLH) Biomedical Research Centre
UCL Experimental Cancer Centre
Fondo de Investigacion Sanitaria (FIS)
Instituto de Salud Carlos III (ISCIII)
Caja de Ahorros de Navarra (CAN) Programme 'Tu eliges, tu decides'
Asociacion Espanola Contra el Cancer (AECC) project
Grant number National Cancer Institute, US National Institutes of Health: U10 CA98543
National Cancer Institute, US National Institutes of Health: U24 CA114766
: PI10/01580
Date 2013-07-01
Published in Nature Genetics. New York: Nature Publishing Group, v. 45, n. 7, p. 799-+, 2013.
ISSN 1061-4036 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 799-+
Access rights Closed access
Type Article
Web of Science ID WOS:000321005200015

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