Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder

Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder

Author Kichuk, Stephen A. Google Scholar
Torres, Albina R. Google Scholar
Fontenelle, Leonardo F. Google Scholar
Rosario, Maria Conceicao Autor UNIFESP Google Scholar
Shavitt, Roseli G. Google Scholar
Miguel, Euripedes C. Google Scholar
Pittenger, Christopher Google Scholar
Bloch, Michael H. Google Scholar
Institution Yale Univ
Universidade de São Paulo (USP)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Abstract Meta-analysis of the heterogeneous symptoms of obsessive-compulsive disorder (OCD) has found a four-factor structure of symptom dimensions consisting of cleaning, forbidden thoughts, symmetry, and hoarding. Research into age of onset of symptom dimensions has yielded inconsistent results, and it is unknown whether symptoms along these dimensions differ in their clinical course. We assessed age of onset and clinical course of different OCD symptom dimensions in a large cohort of adult patients. Nine-hundred fifty-five subjects were assessed using the Dimensional Yale-Brown Obsessive-Compulsive Scale. for age of onset analysis, we tested across three methods of classification: (1) primary (more severe) symptom dimension (2) clinically significant symptoms within a dimension or (3) any symptoms within a dimension. Age of onset was defined as the earliest age of onset reported for any individual item within a symptom dimension. for analysis of different types of clinical course, we used chi-square tests to assess for differences between primary symptom dimensions. OCD symptoms in the symmetry dimension had an earlier age of onset than other OCD symptom dimensions. These findings remained significant across all three methods of classification and controlling for gender and comorbid tics. No significant differences were found between the other dimensions. Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course. (C) 2013 Published by Elsevier Inc.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
National Institute of Mental Health
National Institutes of Health
APIRE/Eli Lilly Psychiatric Research Fellowship
AACAP/Eli Lilly Junior Investigator Award
Trichotillomania Learning Center
NARSAD
Doris Duke Charitable Foundation
National Center for Research Resources, a component of the National Institutes of Health
NIH roadmap for Medical Research
Grant number FAPESP: 2005/55628-8
CNPq: 573974/2008-0
National Institutes of Health: K23MH091240
National Institutes of Health: K08MH081190
National Center for Research Resources, a component of the National Institutes of Health: UL1 RR024139
Date 2013-07-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 44, p. 233-239, 2013.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 233-239
Origin http://dx.doi.org/10.1016/j.pnpbp.2013.02.003
Access rights Closed access
Type Article
Web of Science ID WOS:000320297400031
URI http://repositorio.unifesp.br/handle/11600/36499

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