Association Between Uric Acid Levels and Obstructive Sleep Apnea Syndrome in a Large Epidemiological Sample

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dc.contributor.author Hirotsu, Camila [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Guindalini, Camila [UNIFESP]
dc.contributor.author Mazzotti, Diego R. [UNIFESP]
dc.contributor.author Bittencourt, Lia R. [UNIFESP]
dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:53Z
dc.date.available 2016-01-24T14:31:53Z
dc.date.issued 2013-06-24
dc.identifier http://dx.doi.org/10.1371/journal.pone.0066891
dc.identifier.citation Plos One. San Francisco: Public Library Science, v. 8, n. 6, 9 p., 2013.
dc.identifier.issn 1932-6203
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36430
dc.description.abstract Introduction: Recurrent hypoxia, which is associated with obstructive sleep apnea syndrome (OSAS), leads to an increase in the degradation of adenosine triphosphatase into xanthine, which in turn increases uric acid concentrations.Objective: the current study aimed to determine whether an association exists between OSAS and uric acid levels in the peripheral blood from a representative population of São Paulo (Brazil).Methods: A population-based survey adopting a probabilistic 3-stage cluster sample of São Paulo was used to represent the population according to gender, age, and socioeconomic class. A total of 1,042 volunteers underwent polysomnography recordings for OSAS diagnosis, blood pressure assessment, and biochemical blood analysis, and answered questionnaires.Results: Uric acid levels were correlated with most important risk factors for OSAS, such as AHI, desaturation time and index, minimum oxyhemoglobin saturation (SpO(2)), blood pressure, cholesterol, BMI, triglycerides and arousal, and with OSAS itself. Also, uric acid was increased in OSAS volunteers even after controlling for all confounders. Hyperuricemic volunteers presented lower mean and minimum SpO(2) and increased desaturation index. Importantly, minimum SpO(2) was a significant predictor of uric acid levels, which in turn was considered an independent predictor for OSAS in the binary logistic model. However, a ROC curve analysis for establishing cut-off points for uric acid levels as a biomarker of OSAS revealed moderate sensitivity and specificity.Conclusion: A strong association was found between uric acid levels and OSAS in a representative sample of the population of São Paulo. Although they do not qualify for a biomarker alone, uric acid levels may be involved in OSAS severity and should be considered in sleep apnea management in the future. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 9
dc.language.iso eng
dc.publisher Public Library Science
dc.relation.ispartof Plos One
dc.rights Acesso aberto
dc.title Association Between Uric Acid Levels and Obstructive Sleep Apnea Syndrome in a Large Epidemiological Sample en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: CEPID 98/14303-3
dc.description.sponsorshipID FAPESP: 10/50129-1
dc.identifier.file WOS000321738400080.pdf
dc.identifier.doi 10.1371/journal.pone.0066891
dc.description.source Web of Science
dc.identifier.wos WOS:000321738400080



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