Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Author Gomes, Caio Perez Autor UNIFESP Google Scholar
Torloni, Maria Regina Autor UNIFESP Google Scholar
Gueuvoghlanian-Silva, Barbara Yasmin Autor UNIFESP Google Scholar
Alexandre, Sandra Maria Autor UNIFESP Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of Study Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. Results Twenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD=0.45, 95% CI 0.341.23). Conclusions New studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.
Keywords Blood specimen collection
gestational diabetes mellitus
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: FAPESP - 10/52547-5
Date 2013-06-01
Published in American Journal of Reproductive Immunology. Hoboken: Wiley-Blackwell, v. 69, n. 6, p. 545-557, 2013.
ISSN 1046-7408 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 545-557
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000318758800004

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