Effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of atrial beta-adrenergic receptors

Effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of atrial beta-adrenergic receptors

Author das Neves, Vander Jose Google Scholar
Tanno, Ana Paula Google Scholar
Cunha, Tatiana Sousa Autor UNIFESP Google Scholar
Fernandes, Tiago Google Scholar
Guzzoni, Vinicius Google Scholar
Silva, Carlos Alberto da Google Scholar
Oliveira, Edilamar Menezes de Google Scholar
Costa Sampaio Moura, Maria Jose Google Scholar
Marcondes, Fernanda Klein Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Metodista Piracicaba
Abstract Aims: This study was performed to assess isolated and combined effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of the beta(1)- and beta(2)-adrenergic receptors in the heart of rats.Main methods: Wistar rats were randomly divided into four groups and submitted to a 6-week treatment with nandrolone and/or resistance training. Cardiac hypertrophy was accessed by the ratio of heart weight to the final body weight. Blood pressure was determined by a computerized tail-cuff system. Electrocardiography analyses were performed. Western blotting was used to access the protein levels of the beta(1)- and beta(2)-adrenergic receptors in the right atrium and left ventricle.Key findings: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased systolic blood pressure depending on the treatment time. Resistance training decreased systolic, diastolic and mean arterial blood pressure, as well as induced resting bradycardia. Nandrolone prolonged the QTc interval for both trained and non-trained groups when they were compared to their respective vehicle-treated one. Nandrolone increased the expression of beta(1)- and beta(2)-adrenergic receptors in the right atrium for both trained and non-trained groups when they were compared to their respective vehicle-treated one.Significance: This study indicated that nandrolone, associated or not with resistance training increases blood pressure depending on the treatment time, induces prolongation of the QTc interval, and increases the expression of beta(1)- and beta(2)-adrenergic receptors in the cardiac right atrium, but not in the left ventricle. (c) 2013 Published by Elsevier Inc.
Keywords Cardiac hypertrophy
Arterial blood pressure
Electrocardiography
Training
Anabolic steroids
Beta-adrenergic receptors
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
FAEPEX/UNICAMP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-05-30
Published in Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 92, n. 20-21, p. 1029-1035, 2013.
ISSN 0024-3205 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1029-1035
Origin http://dx.doi.org/10.1016/j.lfs.2013.04.002
Access rights Closed access
Type Article
Web of Science ID WOS:000319853600011
URI http://repositorio.unifesp.br/handle/11600/36353

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