Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases

Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases

Author Casalechi, Heliodora Leao Google Scholar
Pinto Leal-Junior, Ernesto Cesar Google Scholar
Xavier, Murilo Google Scholar
Silva, Jose Antonio Google Scholar
Tarso, Paulo de Google Scholar
Carvalho, Camillo de Google Scholar
Aimbire, Flavio Autor UNIFESP Google Scholar
Albertini, Regiane Google Scholar
Institution Nove de Julho Univ UNINOVE
Univ Camilo Castelo Branco
Vale Jequitinhonha & Mucuri Fed Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract A variety of treatments for tendinopathies is currently used or has been trialed. However, in fact, there is a remarkably little evidence that any conventional therapies are effective. in the last years, low-level laser therapy (LLLT) has been showing interesting results in inflammatory modulation in different musculoskeletal disorders, but the optimal parameters and mechanisms behind these effects are not fully understood. the aim of this study is to investigate if the LLLT modulates the acute and chronic phase of collagenase-induced tendinitis in rat by interfering in mRNA expression for matrix metalloproteinases (MMP13 and MMP1), vascular endothelial growth factor (VEGF), and anti-inflammatory mediator (interleukin (IL)-10). for such, tendinitis was induced by collagenase injection in male Wistar rats. Animals were treated with LLLT (780 nm, potency of 22 mW, 107 mW/cm(2), energy density of 7.5 J/cm(2), and energy delivered of 1.54 J) with different number of treatments in accordance with the inflammatory phase analyzed. LLLT was able to modulate mRNA gene expression of IL-10, VGEF, MMP1, and MMP13 both in acute than in chronic inflammatory phase (p < 0.05). Our results suggest that LLLT with parameters employed in the present study was able to modulate IL-10, VEGF, MMP1, and MMP13 mRNA gene expression both in acute than in chronic tendon inflammation. However, further studies are needed to establish optimal parameters for LLLT.
Keywords LLLT
Inflammatory mediators
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/05890-9
FAPESP: 2012/02087-3
Date 2013-05-01
Published in Lasers in Medical Science. London: Springer London Ltd, v. 28, n. 3, p. 989-995, 2013.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 989-995
Origin http://dx.doi.org/10.1007/s10103-012-1189-x
Access rights Closed access
Type Article
Web of Science ID WOS:000318184600037
URI http://repositorio.unifesp.br/handle/11600/36277

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