Assessment of the Toxicity of the Brazilian Pepper Trees Schinus terebinthifolius Raddi (Aroeira-da-praia) and Myracrodruon urundeuva AllemAo (Aroeira-do-sertAo)

Assessment of the Toxicity of the Brazilian Pepper Trees Schinus terebinthifolius Raddi (Aroeira-da-praia) and Myracrodruon urundeuva AllemAo (Aroeira-do-sertAo)

Author Carlini, Elisaldo Araujo Autor UNIFESP Google Scholar
Duarte-Almeida, Joaquim Mauricio Autor UNIFESP Google Scholar
Tabach, Ricardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Sao Joao Del Rei
Univ Santo Amaro
Abstract The present study aimed to assess the preclinical toxicity of two plants commonly used to treat stomach ailments in Brazil: Schinus terebinthifolius Raddi (S) and Myracrodruon urundeuva AllemAo (M). in male rats, chronic treatment (83days) with both pepper trees (17.6 and 13.8mg/kg, S and M, respectively) has been shown to decrease hematocrit. However, a reduction in the number of red blood cells and hemoglobin was only seen following administration of S. terebinthifolius. None of the plants caused anatomopathological alterations following chronic treatment, and mating ability and fertility were not affected. Both pepper trees showed moderate toxicity following acute and chronic treatment by gavage, particularly S. terebinthifolius. Moreover, bone malformations were induced in fetuses, and a slight delay in recovery time of the postural reflex was observed in pups from female animals treated (18days) with S. terebinthifolius. Given these results, a better assessment of the risks and benefits of the internal use of these plants is necessary, especially when used by women of childbearing age. Copyright (c) 2012 John Wiley & Sons, Ltd.
Keywords Schinus terebinthifolius
Myracrodruon urundeuva
toxicity
malformations
Language English
Sponsor Research Incentive Fund Association (Associacao Fundo Incentivo a Pesquisa-AFIP)
Date 2013-05-01
Published in Phytotherapy Research. Hoboken: Wiley-Blackwell, v. 27, n. 5, p. 692-698, 2013.
ISSN 0951-418X (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 692-698
Origin http://dx.doi.org/10.1002/ptr.4767
Access rights Closed access
Type Article
Web of Science ID WOS:000318031500009
URI http://repositorio.unifesp.br/handle/11600/36269

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