CCR5 genotypes and progression to HIV disease in perinatally infected children

CCR5 genotypes and progression to HIV disease in perinatally infected children

Author Angelis, Daniela Souza Araújo de Google Scholar
Freire, Wilton Santos Google Scholar
Pannuti, Cláudio Sergio Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Machado, Daisy Maria Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The CCR5 molecule, a chemokine receptor, is the most important co-receptor for macrophage-tropic HIV-1. A 32-bp deletion in the gene encoding CCR5 (CCR5-del32) confers nearly complete resistance to HIV-1 infection in homozygotes, and slows the rate of progression to AIDS in heterozygous adults. The aim of this study was to describe the CCR5 genotypes and the characteristics of HIV disease progression in perinatally infected children. From a total of 51 children analyzed for the CCR5-del32 mutation, 18 (35%) were considered to be rapid progressors, 28 (55%) were moderate progressors and 5 (10%) were slow progressors. A portion of the CCR5 gene was amplified by PCR from genomic DNA followed by agarose gel electrophoresis. Forty-nine children (96%) carried the homozygous wild type genotype for CCR5 while 2 (4%) carried the heterozygous wt/del32 genotype. In the population studied, the CCR5 genotype was unable to account for the differences in pattern of the disease progression among the three groups (rapid, moderate and slow progressors), and the allele frequency of CCR5-del32 was too low to allow statistical comparisons with adequate resolving power. Studies on larger populations may help to further elucidate the role of this allele and other host factors in the regulation of HIV-1 pathogenesis in children.
Keywords HIV-1
CCR5 co-receptor
HIV disease progression
perinatally infected children
Language English
Date 2007-04-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 2, p. 196-198, 2007.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Brazilian Society of Infectious Diseases
Extent 196-198
Origin http://dx.doi.org/10.1590/S1413-86702007000200004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000254388400004
SciELO ID S1413-86702007000200004 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/3625

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