Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus

Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus

Author Leite, Cleo A. C. Autor UNIFESP Google Scholar
Taylor, Edwin W. Google Scholar
Wang, Tobias Google Scholar
Abe, Augusto S. Google Scholar
Andrade, Denis O. V. de Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Birmingham
Universidade de São Paulo (USP)
Aarhus Univ
Abstract The morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. the higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate. Oxygen uptake recorded at rest and during spontaneous and forced activity was not affected by removing control of the cardiac shunt. Furthermore, metabolic rate and energetic balance during the post-prandial metabolic increment, plus the food conversion efficiency and growth rate, were all similarly unaffected. These results show that control of cardiac shunting is not associated with a clear functional advantage in adjusting metabolic rate, effectiveness of digestion or growth rates.
Keywords cardiac shunt
vagotomy
rattlesnake
Crotalus
oxygen uptake
heart
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Danish Research Council
Date 2013-05-01
Published in Journal of Experimental Biology. Cambridge: Company of Biologists Ltd, v. 216, n. 10, p. 1881-1889, 2013.
ISSN 0022-0949 (Sherpa/Romeo, impact factor)
Publisher Company of Biologists Ltd
Extent 1881-1889
Origin http://dx.doi.org/10.1242/jeb.083840
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000318483600021
URI http://repositorio.unifesp.br/handle/11600/36247

Show full item record




File

Name: WOS000318483600021.pdf
Size: 1.656Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account