Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma

Comparison of Different Spectral Domain OCT Scanning Protocols for Diagnosing Preperimetric Glaucoma

Autor Lisboa, Renato Autor UNIFESP Google Scholar
Paranhos Junior, Augusto Autor UNIFESP Google Scholar
Weinreb, Robert N. Google Scholar
Zangwill, Linda M. Google Scholar
Leite, Mauro Toledo Autor UNIFESP Google Scholar
Medeiros, Felipe Andrade Autor UNIFESP Google Scholar
Instituição Univ Calif San Diego
Universidade Federal de São Paulo (UNIFESP)
Resumo PURPOSE. To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.METHODS. the study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session. Forty-eight eyes with progressive glaucomatous damage were included in the preperimetric glaucoma group. Ninety-four eyes without any evidence of progressive glaucomatous damage and followed untreated for 12.8 +/- 3.6 years were used as controls. Areas under the receiver operating characteristic curves (AUC) were calculated to summarize diagnostic accuracies of the parameters.RESULTS. the three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 +/- 0.03), inferior hemisphere average thickness (0.87 +/- 0.03), and inferior quadrant average thickness (0.85 +/- 0.03). the three ONH parameters with the largest AUCs were vertical cup-to-disc ratio (0.74 +/- 0.04), rim area (0.72 +/- 0.05), and rim volume (0.72 +/- 0.05). the three macular parameters with the largest AUCs were GCC average thickness (0.79 +/- 0.04), GCC inferior thickness (0.79 +/- 0.05), and GCC superior thickness (0.76 +/- 0.05). Average RNFL thickness performed better than vertical cup-to-disc ratio (0.89 vs. 0.74; P = 0.007) and GCC average thickness (0.89 vs. 0.79; P = 0.015).CONCLUSIONS. SDOCT RNFL measurements performed better than ONH and macular measurements for detecting preperimetric glaucomatous damage in a cohort of glaucoma suspects.
Palavra-chave preperimetric
glaucoma
diagnosis
Idioma Inglês
Financiador National Institutes of Health/National Eye Institute
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Research to Prevent Blindness (New York, New York)
Alcon
Allergan
Pfizer
Merck
Santen
Número do financiamento National Institutes of Health/National Eye Institute: EY021818
National Institutes of Health/National Eye Institute: EY11008
National Institutes of Health/National Eye Institute: EY14267
CAPES: 1066/11-0
Data de publicação 2013-05-01
Publicado em Investigative Ophthalmology & Visual Science. Rockville: Assoc Research Vision Ophthalmology Inc, v. 54, n. 5, p. 3417-3425, 2013.
ISSN 0146-0404 (Sherpa/Romeo, fator de impacto)
Publicador Assoc Research Vision Ophthalmology Inc
Extensão 3417-3425
Fonte http://dx.doi.org/10.1167/iovs.13-11676
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000321118300039
Endereço permanente http://repositorio.unifesp.br/handle/11600/36244

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta