The effects of joint immobilization on articular cartilage of the knee in previously exercised rats

The effects of joint immobilization on articular cartilage of the knee in previously exercised rats

Autor Maldonado, Diogo Correa Autor UNIFESP Google Scholar
Pereira da Silva, Marcelo Cavenaghi Autor UNIFESP Google Scholar
Neto, Semaan El-Razi Google Scholar
Souza, Monica Rodrigues de Google Scholar
Souza, Romeu Rodrigues de Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Nove de Julho Univ
Univ Sao Judas Tadeu
Resumo Studies have determined the effects of joint immobilization on the articular cartilage of sedentary animals, but we are not aware of any studies reporting the effects of joint immobilization in previously trained animals. the objective of the present study was to determine whether exercise could prevent degeneration of the articular cartilage that accompanies joint immobilization. We used light microscopy to study the thickness, cell density, nuclear size, and collagen density of articular cartilage of the femoral condyle of Wistar rats subjected to aerobic physical activity on an adapted treadmill five times per week. Four groups of Wistar rats were used: a control group (C), an immobilized group (I), an exercised group (E), and an exercised and then immobilized group (EI). the right knee joints from rats in groups I and EI were immobilized at 90 degrees C of flexion using a plastic cast for 8weeks. Cartilage thickness decreased significantly in group I (mean, 120.14 +/- 15.6m, P<0.05), but not in group EI (mean, 174 +/- 2.25), and increased significantly in group E (mean, 289.49 +/- 9.15) compared with group C (mean, 239.20 +/- 6.25). the same results were obtained for cell density, nuclear size, and collagen density (in all cases, P<0.05). We concluded that exercise can prevent degenerative changes in femoral articular cartilage caused by immobilization of the knee joint.
Palavra-chave articular cartilage
exercise
immobilization
knee joint
Idioma Inglês
Data de publicação 2013-05-01
Publicado em Journal of Anatomy. Hoboken: Wiley-Blackwell, v. 222, n. 5, p. 518-525, 2013.
ISSN 0021-8782 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 518-525
Fonte http://dx.doi.org/10.1111/joa.12036
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000317905900004
Endereço permanente http://repositorio.unifesp.br/handle/11600/36242

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