Chromatin modifications in trypanosomes due to stress

Chromatin modifications in trypanosomes due to stress

Autor Moretti, Nilmar Silvio Autor UNIFESP Google Scholar
Schenkman, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Trypanosomatids are parasites of worldwide distribution with relevant importance in human and veterinary health, which inhabit invertebrate and vertebrate hosts, such that they are exposed to large environmental variations during their life cycle. the signalling mechanisms and molecular basis that lead these parasites to adjust to such distinct conditions are beginning to be understood, and are somehow related to modifications in gene expression. Although the control of gene expression in this group of organisms happens predominantly at the post-transcriptional level, they present modifications in chromatin that has been implicated in transcription initiation, replication and DNA repair. Here, we explore the current scenario of chromatin alterations in these protozoans and how these changes affect transcription, replication and DNA repair in response to environmental modifications.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data de publicação 2013-05-01
Publicado em Cellular Microbiology. Hoboken: Wiley-Blackwell, v. 15, n. 5, p. 709-717, 2013.
ISSN 1462-5814 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 709-717
Fonte http://dx.doi.org/10.1111/cmi.12111
Direito de acesso Acesso aberto Open Access
Tipo Resenha
Web of Science WOS:000317865900003
Endereço permanente http://repositorio.unifesp.br/handle/11600/36241

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