Chromatin modifications in trypanosomes due to stress

Chromatin modifications in trypanosomes due to stress

Author Moretti, Nilmar Silvio Autor UNIFESP Google Scholar
Schenkman, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Trypanosomatids are parasites of worldwide distribution with relevant importance in human and veterinary health, which inhabit invertebrate and vertebrate hosts, such that they are exposed to large environmental variations during their life cycle. the signalling mechanisms and molecular basis that lead these parasites to adjust to such distinct conditions are beginning to be understood, and are somehow related to modifications in gene expression. Although the control of gene expression in this group of organisms happens predominantly at the post-transcriptional level, they present modifications in chromatin that has been implicated in transcription initiation, replication and DNA repair. Here, we explore the current scenario of chromatin alterations in these protozoans and how these changes affect transcription, replication and DNA repair in response to environmental modifications.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-05-01
Published in Cellular Microbiology. Hoboken: Wiley-Blackwell, v. 15, n. 5, p. 709-717, 2013.
ISSN 1462-5814 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 709-717
Origin http://dx.doi.org/10.1111/cmi.12111
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000317865900003
URI http://repositorio.unifesp.br/handle/11600/36241

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