PHARMACOKINETICS and PHARMACODYNAMICS of ANTIMICROBIAL DRUGS in INTENSIVE CARE UNIT PATIENTS

PHARMACOKINETICS and PHARMACODYNAMICS of ANTIMICROBIAL DRUGS in INTENSIVE CARE UNIT PATIENTS

Autor Macedo, Rodrigo Spineli Autor UNIFESP Google Scholar
Onita, Julio Henrique Autor UNIFESP Google Scholar
Wille, Marcos Paulo Autor UNIFESP Google Scholar
Furtado, Guilherme Henrique Campos Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Inappropriate use of antimicrobial drugs is responsible for therapeutic failures, increased mortality rates, and the emergence of resistance. Antimicrobial activity is determined by intrinsic pharmacokinetics/pharmacodynamics concepts. in critically ill patients, an inappropriate dosing regimen can be caused by the inability of an antimicrobial drug to reach adequate concentrations at the infection site owing to alterations in the drug's pharmacokinetics caused by pathophysiological changes. Understanding these concepts and changes in PK-PD parameters that occur in intensive care unit patients is crucial for the optimization of antimicrobial therapy in these patients.
Palavra-chave Pharmacokinetics
pharmacodynamics
antimicrobial drugs
intensive care unit
Idioma Inglês
Data de publicação 2013-05-01
Publicado em Shock. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 7, p. 24-28, 2013.
ISSN 1073-2322 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 24-28
Fonte http://dx.doi.org/10.1097/SHK.0b013e31828faec0
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000330251000006
Endereço permanente http://repositorio.unifesp.br/handle/11600/36236

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