IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients

IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients

Autor Lopes, Matheus Rodrigues Google Scholar
Traina, Fabíola Google Scholar
Campos, Paula de Melo Google Scholar
Pereira, João Kleber Novais Google Scholar
Machado-Neto, João Agostinho Google Scholar
Machado, Helymar da Costa Google Scholar
Gilli, Simone Cristina Olenscki Google Scholar
Saad, Sara Teresinha Olalla Google Scholar
Favaro, Patricia Autor UNIFESP Google Scholar
Instituição Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved.
Palavra-chave Myelodysplastic Syndrome
IL10
CD8(+) cells
Immune System
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2013-05-01
Publicado em Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 37, n. 5, p. 541-546, 2013.
ISSN 0145-2126 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 541-546
Fonte http://dx.doi.org/10.1016/j.leukres.2013.01.019
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000317264500012
Endereço permanente http://repositorio.unifesp.br/handle/11600/36229

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