Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

Autor Balsalobre, Leonardo Autor UNIFESP Google Scholar
Pezato, Rogerio Autor UNIFESP Google Scholar
Perez-Novo, Claudina Google Scholar
Alves, Maria Teresa S. Autor UNIFESP Google Scholar
Santos, Rodrigo P. Autor UNIFESP Google Scholar
Bachert, Claus Google Scholar
Weckx, Luc L. M. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Ghent
Resumo Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.
Palavra-chave TGF-beta 1
Nasal polyps
Rhinosinusitis
Mucosa
Idioma Inglês
Data de publicação 2013-04-15
Publicado em Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
ISSN 1916-0216 (Sherpa/Romeo, fator de impacto)
Publicador Biomed Central Ltd
Extensão 5
Fonte http://dx.doi.org/10.1186/1916-0216-42-29
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000318410400001
Endereço permanente http://repositorio.unifesp.br/handle/11600/36209

Exibir registro completo




Arquivo

Nome: WOS000318410400001.pdf
Tamanho: 3.160MB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta