Adiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance status

Adiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance status

Autor Crispim, Felipe Autor UNIFESP Google Scholar
Vendramini, Marcio F. Autor UNIFESP Google Scholar
Moises, Regina S. Autor UNIFESP Google Scholar
Japanese Brazilian Diabetes Study Group Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Adiponectin circulates in different multimer complexes comprised of low molecular weight trimeric form (LMW), hexamer of middle molecular weight (MMW) and high molecular weight multimers (HMW). in Japanese-Brazilians, a population with high prevalence of glucose metabolism disturbances, we examined the associations of total adiponectin and its multimers with diabetes mellitus.Methods: Two study groups were examined: 26 patients with diabetes mellitus (DM, 14 women and 12 men, aged 55.3 +/- 8.6 years) and 27 age-matched control subjects with normal glucose tolerance (NGT, 12 women and 15 men, aged 54.0 +/- 9.2 years).Results: We found no significant differences in total [NGT: 6.90 ug/ml (4.38-13.43); DM: 5.38 ug/ml (3.76-8.56), p = 0.35], MMW [NGT: 2.34 ug/ml (1.38-3.25); DM: 1.80 ug/ml (1.18-2.84), p = 0.48] or LMW adiponectin [NGT: 2.07 ug/ml (1.45-3.48), DM: 2.93 ug/ml (1.78-3.99), p = 0.32] between groups. in contrast, HMW adiponectin levels were significantly lower in patients with DM [TGN: 2.39 ug/ml (1.20-4.75); DM: 1.04 ug/ml (0.42-1.60), p = 0.001]. A logistic regression analysis was done to identify independent associations with diabetes mellitus. the results showed that HOMA-IR and HMW adiponectin in women were independently associated with diabetes mellitus.Conclusion: the current investigation demonstrates that in Japanese-Brazilians HMW adiponectin is selectively reduced in individuals with type 2 diabetes, while no differences were found in MMW and LMW adiponectin isoforms.
Palavra-chave Adiponectin
HMW adiponectin
Japanese-Brazilians
Idioma Inglês
Data de publicação 2013-04-09
Publicado em Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 5, 6 p., 2013.
ISSN 1758-5996 (Sherpa/Romeo, fator de impacto)
Publicador Biomed Central Ltd
Extensão 6
Fonte http://dx.doi.org/10.1186/1758-5996-5-20
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000317646600001
Endereço permanente http://repositorio.unifesp.br/handle/11600/36201

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