Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants

Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants

Autor Borges, Juliana Policastro Grassano Autor UNIFESP Google Scholar
Dos Santos, Amelia Miyashiro Autor UNIFESP Google Scholar
Cunha, Deyse Helena Fernandes da Autor UNIFESP Google Scholar
Mimica, Ana Flavia de Mello Almada Autor UNIFESP Google Scholar
Guinsburg, Ruth Autor UNIFESP Google Scholar
Kopelman, Benjamin Israel Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background and Objectives Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants. Methods A retrospective cohort of preterm infants with a birth weight of <1500g had been born in 2 periods. in Period 1, a transfusion was indicated for a platelet count of <50000/ml in clinically stable neonates or <100000/ml in bleeding or clinically unstable infants. in Period 2, the indications were restricted to <25000/ml in clinically stable neonates, or <50000/ml in newborns who were either on mechanical ventilation, subject to imminent invasive procedures, within 72h following a seizure, or extremely premature and <7days old. A count of <100000/ml was indicated for bleeding or major surgery. Results Periods 1 and 2 comprised 121 and 134 neonates, respectively. the rates of ventricular haemorrhage and intrahospital death were similar in both periods. the percentage of transfused infants, the odds of receiving a platelet transfusion, the mean platelet count before transfusion and the percentage of transfusions with a platelet count >50,000/ml were greater in Period 1. Among thrombocytopenic neonates, the percentage of transfused neonates and the number of transfusions were similar in both groups. Conclusion the restrictive guideline for platelet transfusions reduced the platelet count thresholds for neonatal transfusions without increasing the rate of ventricular haemorrhage.
Palavra-chave guideline
infant
neonatal intensive care unit
platelet transfusion
thrombocytopenia
very low birth weight
Idioma Inglês
Data de publicação 2013-04-01
Publicado em Vox Sanguinis. Hoboken: Wiley-Blackwell, v. 104, n. 3, p. 207-213, 2013.
ISSN 0042-9007 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 207-213
Fonte http://dx.doi.org/10.1111/j.1423-0410.2012.01658.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000316680300003
Endereço permanente http://repositorio.unifesp.br/handle/11600/36183

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