An exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: A multicentre study

An exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: A multicentre study

Autor Moreira, Luciana Google Scholar
Bins, Helena Google Scholar
Toressan, Ricardo Google Scholar
Ferro, Claudia Google Scholar
Harttmann, Thiago Google Scholar
Petribu, Katia Google Scholar
Juruena, Mario Francisco Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Ferrao, Ygor Arzeno Google Scholar
Instituição Brazilian Res Consortium Obsess Compuls Spectrum
Fed Univ Hlth Sci Porto Alegre
Universidade de São Paulo (USP)
Universidade Federal de Pernambuco (UFPE)
Universidade Federal de São Paulo (UNIFESP)
Kings Coll London
President Vargas Hosp Mothers & Children
Resumo Objective: in women with obsessive-compulsive disorder (OCD), symptom severity appears to fluctuate over the course of the menstrual cycle. the objective of this paper was to compare female OCD patients with and without premenstrual worsening of obsessive-compulsive symptoms (OCS), in terms of the clinical characteristics of OCD.Methods: This was a cross-sectional study involving 455 women with OCD, of whom 226 (49.7%) had experienced premenstrual OCS worsening and 229 (50.3%) had not (PMOCS-worse and PMOCS-same groups, respectively). Data were collected with the original and dimensional versions of the Yale-Brown Obsessive-Compulsive Scale, as well as with the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI).Results: We found significant differences between the PMOCS-same and PMOCS-worse groups, the latter showing a higher frequency of suicidal ideation (P<.001), suicide attempts (P=.027), current use of selective serotonin reuptake inhibitors (P=.022), lifetime use of mood stabilisers (P=.015), and sexual/religious obsessions (P<.001; OR=1.90), as well as higher scores on the BDI (P<.001) and BAI (P<.001).Conclusion: Underscoring the fact that OCD is a heterogeneous disorder, there appears to be a subgroup of female OCD patients in whom the premenstrual period is associated with a higher frequency of sexual/religious obsessions, depression, anxiety, and suicidality. This might be attributable to hormonal fluctuations. Further studies are warranted in order to investigate this hypothesis by evaluating such patients at different phases of the menstrual cycle, as well as measuring hormonal levels. (C) 2012 Elsevier Inc. All rights reserved.
Assunto Obsessive-compulsive symptoms
Premenstrual period
Symptom dimensions
Luteal phase
Idioma Inglês
Data 2013-04-01
Publicado em Journal of Psychosomatic Research. Oxford: Pergamon-Elsevier B.V., v. 74, n. 4, p. 313-319, 2013.
ISSN 0022-3999 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 313-319
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000316586600008

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