Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia

Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia

Autor Noto, Cristiano Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Spindola, Leticia M. Autor UNIFESP Google Scholar
Rocha, Natalia Pessoa Google Scholar
Miranda, Aline Silva de Google Scholar
Teixeira, Antonio Lucio Google Scholar
Cardoso Smith, Marilia Arruda Autor UNIFESP Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Resumo Background: Schizophrenia (SZ) has been associated with an imbalance in the inflammatory cytokine TNF-alpha. the objectives of this study were to compare TNF-alpha and its soluble receptors' serum levels in individuals with SZ with the levels found in a group of healthy volunteers and to investigate the possible association between these biomarkers and the dimensions and severity of symptoms, clinical outcomes and response to treatment in patients with SZ.Methods: Fifty-four chronically medicated SZ outpatients and 118 healthy controls were included in the study. TNF-alpha levels were measured by Cytometric Bead Assay (CBA), and serum levels of soluble tumor necrosis factor receptor 1 (sTNFR1) and soluble tumor necrosis factor receptor 2 (sTNFR2) were measured by ELISA.Results: sTNFR1 and sTNFR2 were significantly elevated in patients with SZ as compared to the healthy control group. in the group of individuals with SZ, the levels of both types of soluble TNF receptors showed a negative correlation with global functioning. sTNFR1 levels were higher in the treatment-resistant patients as compared to the non-treatment-resistant patients and the controls. sTNFR1 levels were also heightened in patients with SZ and concomitant depression.Conclusion: Our findings reinforce that SZ is associated with an inflammatory profile and suggest that sTNFR1 is a marker of a treatment-resistance and severe clinical course in SZ. (C) 2013 Elsevier B.V. All rights reserved.
Palavra-chave Schizophrenia
Biomarkers
Immune system
Inflammation
TNF-alpha
TNF-alpha receptors
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Data de publicação 2013-04-01
Publicado em Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 47, n. 4, p. 467-471, 2013.
ISSN 0022-3956 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 467-471
Fonte http://dx.doi.org/10.1016/j.jpsychires.2012.12.010
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000317027700006
Endereço permanente http://repositorio.unifesp.br/handle/11600/36162

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