A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

Autor Ventura, Janaina Souza Autor UNIFESP Google Scholar
Faria, Fernanda Google Scholar
Correia Batista, Isabel Fatima Google Scholar
Simons, Simone Michaela Autor UNIFESP Google Scholar
Lourenco Oliveira, Daniella Gorete Autor UNIFESP Google Scholar
Morais, Katia L. P. Autor UNIFESP Google Scholar
Chudzinski-Tavassi, Ana Marisa Autor UNIFESP Google Scholar
Instituição Inst Butantan
Universidade Federal de São Paulo (UNIFESP)
Resumo Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. in this study was demonstrated that the Amblyomin-X (which is a recombinant protein that exerts similarity to the Kunitz-type inhibitors and shows pro-apoptotic effects in different tumor cell lines) and heparin (a classic anticoagulant) have similar effects on cancer progression and on normalization of the hypercoagulable state. However, Amblyomin-X showed a distinct mechanism in triggering its effects in vitro, because it exerted a cytotoxic effect in cancer cells by inducing apoptosis and promoting cell cycle arrest. (C) 2013 Elsevier Masson SAS. All rights reserved.
Assunto Amblyomin-X
Heparin
Antitumor
Apoptosis
Coagulation
Cell cycle
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CAT/CEPID
FINEP
Data 2013-04-01
Publicado em Biomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 67, n. 3, p. 192-196, 2013.
ISSN 0753-3322 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 192-196
Fonte http://dx.doi.org/10.1016/j.biopha.2012.11.009
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000317098900002
URI http://repositorio.unifesp.br/handle/11600/36156

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