Characterization of cell-free circulating DNA in plasma in patients with prostate cancer

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dc.contributor.author Delgado, Pamela Oliveira
dc.contributor.author Alves, Beatriz Costa A.
dc.contributor.author Gehrke, Flavia de Sousa
dc.contributor.author Kuniyoshi, Renata Kelly
dc.contributor.author Wroclavski, Marcelo Langer
dc.contributor.author Del Giglio, Auro
dc.contributor.author Affonso Fonseca, Fernando Luiz [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:30Z
dc.date.available 2016-01-24T14:31:30Z
dc.date.issued 2013-04-01
dc.identifier http://dx.doi.org/10.1007/s13277-012-0634-6
dc.identifier.citation Tumor Biology. Dordrecht: Springer, v. 34, n. 2, p. 983-986, 2013.
dc.identifier.issn 1010-4283
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36151
dc.description.abstract Cell-free circulating DNA in plasma and serum may serve as a biomarker for malignant tumor detection and follow up in patients with a variety of solid tumors including prostate cancer. in healthy patients, DNA is normally released from an apoptotic source which generates small fragments of cell-free DNA, whereas cancer patients have cell-free circulating DNA that originated from necrosis, autophagy, or mitotic catastrophe. Cell-free circulating DNA levels were measured by a quantitative real-time PCR method with a set of primers targeted to amplify the consensus ALU apoptotic versus necrotic origin. Prostate cancer patients before and 3 months after diagnosis showed cell-free circulating DNA released at apoptotic and non-apoptotic cell death. Interestingly, all patients after 6 months demonstrated DNA released at non-apoptotic cell. the principal source of cell-free circulating DNA is of apoptotic and non-apoptotic cell death. However, during treatment, this feature could change. Therefore, the study of cell-free circulating DNA would be important to follow the evolution of the disease during the treatment. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 983-986
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Tumor Biology
dc.rights Acesso restrito
dc.subject Prostate Cancer en
dc.subject Cell-free circulating DNA en
dc.subject DNA integrity en
dc.subject ALU sequence en
dc.title Characterization of cell-free circulating DNA in plasma in patients with prostate cancer en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution FMABC
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation FMABC, Oncol Hematol Discipline, São Paulo, Brazil
dc.description.affiliation FMABC, Urol Discipline, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 10/50490-6
dc.identifier.doi 10.1007/s13277-012-0634-6
dc.description.source Web of Science
dc.identifier.wos WOS:000316364500044



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