Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [H-3]-L-glutamate binding in the membranes of brain regions

Relationship between thresholds to convulsions induced by a benzodiazepine inverse agonist and [H-3]-L-glutamate binding in the membranes of brain regions

Autor Contó, Marcos Brandão Autor UNIFESP Google Scholar
Barbosa de Carvalho, Jose Gilberto Autor UNIFESP Google Scholar
Venditti, Marco Antonio Campana Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Although some studies have investigated the influence of kindling model of epilepsy on the glutamatergic neurotransmission, the relation between glutamatergic receptors and seizure susceptibility remains unclear. the present study sought to determine if rats with high (HTR) and low (LTR) thresholds to clonic convulsions induced by the benzodiazepine inverse agonist DMCM differed in the [H-3]-l-glutamate binding to membranes from discrete brain regions. Compared to the HTR subgroup, the LTR subgroup presented a lower binding of [H-3]-l-glutamate in the hippocampus, frontal cortex and amygdala plus limbic cortex, suggesting that glutamatergic receptors in these brain regions may underlie the susceptibility to DMCM-induced convulsions.
Palavra-chave Convulsion
Seizure
[H-3]-L-glutamate
Binding
Benzodiazepine inverse agonist
DMCM
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa (AFIP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2013-04-01
Publicado em Neurological Sciences. New York: Springer, v. 34, n. 4, p. 537-538, 2013.
ISSN 1590-1874 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 537-538
Fonte http://dx.doi.org/10.1007/s10072-012-1093-y
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000317348400017
Endereço permanente http://repositorio.unifesp.br/handle/11600/36146

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta