Nandrolone Decanoate Induces Genetic Damage in Multiple Organs of Rats

Nandrolone Decanoate Induces Genetic Damage in Multiple Organs of Rats

Autor Pozzi, Renan Autor UNIFESP Google Scholar
Fernandes, Kelly Rosseti Autor UNIFESP Google Scholar
Gomes de Moura, Carolina Foot Autor UNIFESP Google Scholar
Mesquita Ferrari, Raquel Agnelli Google Scholar
Santos Fernandes, Kristianne Porta Google Scholar
Muniz Renno, Ana Claudia Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Nove de Julho Unvers
Resumo To evaluate the impact potential of nandrolone decanoate on DNA damage in multiple organs of Wistar rats by means of single-cell gel (comet) assay and micronucleus test. A total of 15 animals were distributed into three groups of five animals each as follows: control group = animal not exposed to nandrolone decanoate; experimental group = animals exposed to nandrolone decanoate for 24 h at 5 mg/kg subcutaneously; and experimental group = animals exposed to nandrolone decanoate for 24 h at 15 mg/kg subcutaneously. Significant statistical differences (p < 0.05) were noted in peripheral blood, liver, and heart cells exposed to nandrolone decanoate at the two doses evaluated. A clear dose-response relationship was observed between groups. Kidney cells showed genetic damage at only the highest dose (15 mg/kg) used. However, micronucleus data did not show remarkable differences among groups. in conclusion, the present study indicates that nandrolone decanoate induces genetic damage in rat blood, liver, heart, and kidney cells as shown by single-cell gel (comet) assay results.
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2013-04-01
Publicado em Archives of Environmental Contamination and Toxicology. New York: Springer, v. 64, n. 3, p. 514-518, 2013.
ISSN 0090-4341 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 514-518
Fonte http://dx.doi.org/10.1007/s00244-012-9848-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000316344200017
Endereço permanente http://repositorio.unifesp.br/handle/11600/36140

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