Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task

Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task

Autor Zanin, Karina A. Autor UNIFESP Google Scholar
Patti, Camilla L. Autor UNIFESP Google Scholar
Sanday, Leandro Autor UNIFESP Google Scholar
Fernandes-Santos, Luciano Autor UNIFESP Google Scholar
Oliveira, Larissa C. Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Zolpidem (Zolp), a hypnotic drug prescribed to treat insomnia, may have negative effects on memory, but reports are inconsistent.We examined the effects of acute doses of Zolp (2, 5, or 10 mg/kg, i.p.) on memory formation (learning, consolidation, and retrieval) using the plus-maze discriminative avoidance task.Mice were acutely treated with Zolp 30 min before training or testing. in addition, the effects of Zolp and midazolam (Mid; a classic benzodiazepine) on consolidation at different time points were examined. the possible role of state dependency was investigated using combined pre-training and pre-test treatments.Zolp produced a dose-dependent sedative effect, without modifying anxiety-like behavior. the pre-training administration of 5 or 10 mg/kg resulted in retention deficits. When administered immediately after training or before testing, memory was preserved. Zolp post-training administration (2 or 3 h) impaired subsequent memory. There was no participation of state dependency phenomenon in the amnestic effects of Zolp. Similar to Zolp, Mid impaired memory consolidation when administered 1 h after training.Amnestic effects occurred when Zolp was administered either before or 2-3 h after training. These memory deficits are not related to state dependency. Moreover, Zolp did not impair memory retrieval. Notably, the memory-impairing effects of Zolp are similar to those of Mid, with the exception of the time point at which the drug can modify consolidation. Finally, the memory effects were unrelated to sedation or anxiolysis.
Palavra-chave Zolpidem
Memory
Consolidation
State dependency
Plus-maze discriminative avoidance task
PM-DAT
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Número do financiamento FAPESP: 1998/14303-3
FAPESP: 2008/08823-8
FAPESP: 2009/00465-8
Data de publicação 2013-04-01
Publicado em Psychopharmacology. New York: Springer, v. 226, n. 3, p. 459-474, 2013.
ISSN 0033-3158 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 459-474
Fonte http://dx.doi.org/10.1007/s00213-012-2756-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000316085800002
Endereço permanente http://repositorio.unifesp.br/handle/11600/36139

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