First report and molecular characterization of hepatitis E virus infection in renal transplant recipients in Brazil

First report and molecular characterization of hepatitis E virus infection in renal transplant recipients in Brazil

Autor Passos, Ana Maria Autor UNIFESP Google Scholar
Heringer, Tiago Pires Autor UNIFESP Google Scholar
Medina-Pestana, Jose Osmar Autor UNIFESP Google Scholar
Gomes Ferraz, Maria Lucia Autor UNIFESP Google Scholar
Hernandes Granato, Celso Francisco Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Hepatitis E virus (HEV) causes acute and chronic hepatitis in organ transplant recipients. Serological evidence for HEV infection has been discovered in various population groups in Brazil, and a single acute case has been confirmed. To date, however, no cases of HEV infection in immunocompromised patients have been reported in Brazil. This study aimed to identify and characterize hepatitis E cases in renal transplant recipients in Brazil. A retrospective study was performed on 96 serum samples from renal transplant recipients with unexplained liver enzymes elevation. Three confirmed cases of HEV infection were identified that lacked seroconversion to HEV IgG antibodies. the prevalence of HEV in these patients was 3.1%. Using a sequence analysis of a 304-nucleotide fragment within ORF2, the strains were classified as genotype 3 with a low percent identity to previously characterized strains. This is the first report of hepatitis E infection in renal transplant recipients in Brazil, and the data indicate that a novel genotype 3 subvariant may be present and that further investigation is necessary to characterize the circulating HEV strains. in this setting, HEV infection should be considered as a potential cause of abnormal liver tests of unknown origin. J. Med. Virol. 85:615619, 2013. (c) 2013 Wiley Periodicals, Inc.
Palavra-chave hepatitis E virus
genotype 3
human
renal transplant recipients
Brazil
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2013-04-01
Publicado em Journal of Medical Virology. Hoboken: Wiley-Blackwell, v. 85, n. 4, p. 615-619, 2013.
ISSN 0146-6615 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 615-619
Fonte http://dx.doi.org/10.1002/jmv.23494
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000315123600008
Endereço permanente http://repositorio.unifesp.br/handle/11600/36137

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