Candida mesorugosa sp nov., a novel yeast species similar to Candida rugosa, isolated from a tertiary hospital in Brazil

Candida mesorugosa sp nov., a novel yeast species similar to Candida rugosa, isolated from a tertiary hospital in Brazil

Author Chaves, Guilherme Maranhão Autor UNIFESP Google Scholar
Terçarioli, Gisela Ramos Autor UNIFESP Google Scholar
Padovan, Ana Carolina Barbosa Autor UNIFESP Google Scholar
Rosas, Robert Fabian Crespo Autor UNIFESP Google Scholar
Ferreira, Renata Carmona Autor UNIFESP Google Scholar
Melo, Analy Salles de Azevedo Autor UNIFESP Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Candida rugosa is a yeast species that is emerging as a causative agent of invasive infection, particularly in Latin America. Recently, C. pseudorugosa was proposed as a new species closely related to C. rugosa. We evaluated in this investigation the genetic heterogeneity within the C. rugosa species complex. All clinical isolates used in this study were identified phenotypically as C. rugosa but were genotypically different from the C. rugosa type, ATCC 10571. RAPD marker analysis revealed less than 83% similarity between our clinical isolates and the C. rugosa type strain. the D1/D2 region sequences of our clinical isolates showed 98% identity with C. rugosa but only 94-95% identity with C. pseudorugosa. the ITS rDNA sequences of the Brazilian isolates showed 91% identity with the C. rugosa ATCC 10571 ITS sequence. Network and Bayesian analyses of ITS and housekeeping gene sequences separated our clinical isolates into different branches from C. rugosa type strain. These differences are sufficient to reassign our isolates to a distinct species, named C. mesorugosa.
Keywords novel Candida species
Candida mesorugosa
Candida rugosa species complex
Language English
Sponsor Astellas
United Medical
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2007/08575-1
FAPESP: 2005/04442-1
FAPESP: 2007/05880-8
Date 2013-04-01
Published in Medical Mycology. London: Informa Healthcare, v. 51, n. 3, p. 231-242, 2013.
ISSN 1369-3786 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 231-242
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316228100002

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