Does Obstructive Sleep Apnea Impair the Cardiopulmonary Response to Exercise?

Does Obstructive Sleep Apnea Impair the Cardiopulmonary Response to Exercise?

Autor Rizzi, Camila Furtado Autor UNIFESP Google Scholar
Cintra, Fatima Autor UNIFESP Google Scholar
Mello-Fujita, Luciane Autor UNIFESP Google Scholar
Rios, Lais França Autor UNIFESP Google Scholar
Mendonça, Elisangela Trevisan de Autor UNIFESP Google Scholar
Feres, Marcia Cristina Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Study Objectives: the aim of this study was to evaluate cardiopulmonary exercise performance in lean and obese patients with obstructive sleep apnea (OSA) compared with controls.Design: Case-control study.Setting: the study was carried out in São Paulo Sleep Institute, São Paulo, Brazil.Patients and Participants: Individuals with similar ages were allocated into groups: 22 to the lean OSA group, 36 to the lean control group, 31 to the obese OSA group, and 26 to the obese control group.Interventions: the participants underwent a clinical evaluation, polysomnography, a maximum limited symptom cardiopulmonary exercise test, two-dimensional transthoracic echocardiography, and spirometry.Measurements and Results: the apnea-hypopnea index, arousal index, lowest arterial oxygen saturation (SaO(2)) and time of SaO(2) < 90% were different among the groups. There were differences in functional capacity based on the following variables: maximal oxygen uptake (VO(2)max), P < 0.01 and maximal carbon dioxide production (VCO(2)max), P < 0.01. the obese patients with OSA and obese controls presented significantly lower VO(2)max and VCO(2)max values. However, the respiratory exchange ratio (RER) and anaerobic threshold (AT) did not differ between groups. Peak diastolic blood pressure (BP) was higher among the obese patients with OSA but was not accompanied by changes in peak systolic BP and heart rate (HR). When multiple regression was performed, body mass index (P < 0.001) and male sex in conjunction with diabetes (P < 0.001) independently predicted VO(2)max (mL/kg/min).Conclusions: the results of this study suggest that obesity alone and sex, when associated with diabetes but not OSA, influenced exercise cardiorespiratory function.
Palavra-chave Exercise
functional capacity
obesity
obstructive sleep apnea
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2013-04-01
Publicado em Sleep. Westchester: Amer Acad Sleep Medicine, v. 36, n. 4, p. 547-553, 2013.
ISSN 0161-8105 (Sherpa/Romeo, fator de impacto)
Publicador Amer Acad Sleep Medicine
Extensão 547-553
Fonte http://dx.doi.org/10.5665/sleep.2542
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000316939000014
Endereço permanente http://repositorio.unifesp.br/handle/11600/36132

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