Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study

Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study

Autor Valentini Neto, Joao Google Scholar
Melo, Camila Maria de Autor UNIFESP Google Scholar
Lima Ribeiro, Sandra Maria Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo We hypothesize that improvements in the gut microbiota are capable of ameliorating gut permeability and, consequently, reducing systemic inflammation and the risk of frailty. This study aims to evaluate some effects of synbiotic supplementation on inflammatory markers and the body composition of the elderly at risk of frailty. in a double-blind study that lasted three months, 17 elderly individuals fulfilling one frailty criteria (grip strength) were randomly distributed into two groups: SYN (n = 9), daily intake of synbiotic (6 g Frutooligossacarides, 10(8) to 10(9) CFU Lactobacillus paracasei, 10(8) to 10(9) CFU Lactobacillus rhamnosus, 10(8) to 10(9) CFU Lactobacillus acidophilus and 10(8) to 10(9) CFU Bifidobacterium lactis), or placebo (maltodextrin; PLA; n = 8). Subjects were analyzed for anthropometric measurements, bioelectric impedance with vectorial analysis (BIVA), IL-6 and TNF-alpha. A comparison between groups did not show any difference for the variables investigated. in turn, individual analysis of electrical impedance (BIVA) demonstrated that the majority of SYN individuals maintained or improved their tissue hydration, when compared to the PLA group after supplementation. in conclusion, three months of synbiotic supplementation did not promote any significant changes in inflammatory cytokines or body composition, but demonstrated a trend towards a preservation of hydration status in apparently healthy elderly individuals.
Palavra-chave symbiotic
body composition
Idioma Inglês
Data de publicação 2013-04-01
Publicado em Nutrients. Basel: Mdpi Ag, v. 5, n. 4, p. 1276-1286, 2013.
ISSN 2072-6643 (Sherpa/Romeo, fator de impacto)
Publicador Mdpi Ag
Extensão 1276-1286
Fonte http://dx.doi.org/10.3390/nu5041276
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000318019300015
Endereço permanente http://repositorio.unifesp.br/handle/11600/36127

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