The human leucocyte antigen DQB1*0602 allele is associated with electroencephelograph differences in individuals with obstructive sleep apnoea syndrome

The human leucocyte antigen DQB1*0602 allele is associated with electroencephelograph differences in individuals with obstructive sleep apnoea syndrome

Autor Manzotte, Thais Autor UNIFESP Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Mazzotti, Diego R. Autor UNIFESP Google Scholar
Palombini, Luciana Autor UNIFESP Google Scholar
De Souza, Altay L. Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Bittencourt, Lia R. A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Human leucocyte antigen (HLA) DQB1*0602 allele, a well-known genetic risk factor for narcolepsy, has been associated with sleep parameters in healthy subjects. We aimed to assess the association of this allele with daytime sleepiness and altered sleep electroencephalogram characteristics in the general population and in patients with obstructive sleep apnoea syndrome (OSAS). Eight hundred and ninety-four individuals from the Epidemiologic Study of Sleep were genotyped for the HLA DQB1*0602 allele. Full-night polysomnography was performed, and daytime sleepiness was analysed according to the Epworth Sleepiness Scale. HLA-DQB1*0602 allele-positive and -negative subjects in the general population, as well as in patients with OSAS, exhibited similar sleep parameters and levels of daytime sleepiness. However, spectral analysis showed that allele-positive individuals with OSAS exhibited higher theta power during sleep Stage 1 (P<0.05) in occipital derivations, and lower delta power during sleep Stages 1 and 2 (P<0.01) compared with individuals negative for the allele, even after correction for potential confounders as age, sex, body mass index and European ancestry. No significant differences in the electroencephalogram variables were found in individuals without OSAS. the data highlight the HLA-DQB1*0602 as a potential genetic factor influencing sleep physiology in individuals diagnosed with OSAS.
Palavra-chave genetic
human leucocyte antigen DQB1*0602 allele
obstructive sleep apnoea syndrome
polymorphism
sleep
spectral analysis
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 07/50 525-1
FAPESP: 98/14 303-3
Data de publicação 2013-04-01
Publicado em Journal of Sleep Research. Hoboken: Wiley-Blackwell, v. 22, n. 2, p. 217-222, 2013.
ISSN 0962-1105 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 217-222
Fonte http://dx.doi.org/10.1111/jsr.12005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000316964100015
Endereço permanente http://repositorio.unifesp.br/handle/11600/36120

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta