Sexual response in female rats with status epilepticus

Sexual response in female rats with status epilepticus

Autor Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Matos, Gabriela Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose Female sexual function is complex and may be disrupted by disease, in particular epilepsy. Chronic seizures in women can have adverse effects on reproductive function, but it has been difficult to dissociate the effects of epilepsy from those related to anticonvulsant medications. the purpose of this study was to evaluate sexual behavior in female rats submitted to pilocarpine-induced status epilepticus (SE). Methods Adult female Wistar rats were given saline or pilocarpine (350mg/kg, i.p.) to induce SE. the groups were distributed according to the treatment or response to pilocarpine: CTRL (control rats maintained in the home-cage after saline administration); NSE (nonstatus epilepticus, rats that did not display convulsive and intermittent seizures after pilocarpine injection) and SE (status epilepticus, rats that displayed convulsive and intermittent seizures after pilocarpine injection). After 50days, sexual receptivity in the female rats was artificially induced via administration of a combination of estradiol and progesterone. Sexual behavior was evaluated during three sessions in the presence of a sexually experienced male rat. Receptivity and proceptivity behaviors, as well as hormones concentrations, were monitored. Key Findings Significant decreases in proceptivity and receptivity behaviors during the three tests were observed in SE female rats. the rejection response was significantly increased in SE rats compared with CTRL or NSE groups. Progesterone, testosterone, and corticosterone were unchanged between the groups. Significance the SE female rats showed lower sexual motivation and performance regardless of their steroid hormones levels.
Palavra-chave Sexual behavior
Pilocarpine model
Epilepsy
Hormones
Female rats
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 10/15110-8
FAPESP: 11/12325-6
FAPESP: 12/05396-7
Data de publicação 2013-04-01
Publicado em Epilepsia. Hoboken: Wiley-Blackwell, v. 54, n. 4, p. 644-648, 2013.
ISSN 0013-9580 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 644-648
Fonte http://dx.doi.org/10.1111/epi.12117
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000316965500013
Endereço permanente http://repositorio.unifesp.br/handle/11600/36119

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