Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey

Consequences of Obstructive Sleep Apnea on Metabolic Profile: A Population-Based Survey

Autor Togeiro, Sonia Maria Autor UNIFESP Google Scholar
Carneiro, Glaucia Autor UNIFESP Google Scholar
Ribeiro Filho, Fernando Flexa Autor UNIFESP Google Scholar
Zanella, Maria Teresa Autor UNIFESP Google Scholar
Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Taddei, Jose A. Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: Epidemiologic studies that control for potential confounders are needed to assess the independent associations of obstructive sleep apnea (OSA) with metabolic abnormalities. the aim of our study was to evaluate the associations of OSA with metabolic abnormalities among the adult population of São Paulo, Brazil.Design and Methods: Questionnaires were applied face-to-face, full night polysomnography (PSG) was performed, and blood samples were collected in a population-based survey in São Paulo, Brazil, adopting a probabilistic three-stage cluster sample method. the metabolic profile included fasting glucose, insulin, and lipid levels. the hepatic insulin resistance index was assessed by the homeostasis model assessment-estimated insulin resistance (HOMA(IR)).Results: A total of 1,042 volunteers underwent PSG. Mild OSA and moderate to severe OSA comprised 21.2% and 16.7% of the population, respectively. Subjects with severe to moderate OSA were older, more obese, had higher fasting glucose, HOMA(IR), and triglycerides (TG) levels than did the mild and non-OSA group (P < 0.001). Multivariate regression analyses showed that an apnea-hypopnea index (AHI) >= 15 and a time of oxy-hemoglobin saturation <90% were independently associated with impaired fasting glucose, elevated TG, and HOMA(IR).Conclusions: the results of this large cross-sectional epidemiological study showed that the associations of OSA and metabolic abnormalities were independent of other risk factors.
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 07/50525-1
FAPESP: 98/14303-3
Data de publicação 2013-04-01
Publicado em Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 4, p. 847-851, 2013.
ISSN 1930-7381 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 847-851
Fonte http://dx.doi.org/10.1002/oby.20288
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000322087800027
Endereço permanente http://repositorio.unifesp.br/handle/11600/36113

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