Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey

Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey

Autor Nucci, Marcio Google Scholar
Queiroz-Telles, Flavio Google Scholar
Alvarado-Matute, Tito Google Scholar
Nora Tiraboschi, Iris Google Scholar
Cortes, Jorge Google Scholar
Zurita, Jeannete Google Scholar
Guzman-Blanco, Manuel Google Scholar
Elena Santolaya, Maria Google Scholar
Thompson, Luis Google Scholar
Sifuentes-Osornio, Jose Google Scholar
Echevarria, Juan I. Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Latin Amer Invasive Mycosis Networ Google Scholar
Instituição Universidade Federal do Rio de Janeiro (UFRJ)
Univ Fed Parana
Hosp Escuela Tegucigalpa
Hosp Clin Jose San Martin
Univ Nacl Colombia
Pontificia Univ Catolica Ecuador
Hosp Vargas de Caracas
Ctr Med Caracas
Univ Chile
Univ Desarrollo
Inst Nacl Ciencias Med & Nutr Salvador Zubiran
Univ Peruana Cayetano Heredia
Universidade Federal de São Paulo (UNIFESP)
Resumo Background: the epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America.Methods: We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized.Results: Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. the overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%.Conclusions: This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.
Idioma Inglês
Financiador independent medical grant from Pfizer Inc.
Data 2013-03-19
Publicado em Plos One. San Francisco: Public Library Science, v. 8, n. 3, 7 p., 2013.
ISSN 1932-6203 (Sherpa/Romeo, fator de impacto)
Editor Public Library Science
Extensão 7
Fonte http://dx.doi.org/10.1371/journal.pone.0059373
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000317562100120
URI http://repositorio.unifesp.br/handle/11600/36092

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