Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL

Autor Rego, Eduardo M. Google Scholar
Kim, Haesook T. Google Scholar
Ruiz-Argueelles, Guillermo J. Google Scholar
Undurraga, Maria Soledad Google Scholar
Uriarte, Maria del Rosario Google Scholar
Jacomo, Rafael H. Google Scholar
Gutierrez-Aguirre, Homero Google Scholar
Melo, Raul A. M. Google Scholar
Bittencourt, Rosane Google Scholar
Pasquini, Ricardo Google Scholar
Pagnano, Katia Google Scholar
Fagundes, Evandro M. Google Scholar
Chauffaille, Maria de Lourdes Autor UNIFESP Google Scholar
Chiattone, Carlos S. Google Scholar
Martinez, Lem Google Scholar
Meillon, Luis A. Google Scholar
Gomez-Almaguer, David Google Scholar
Kwaan, Hau C. Google Scholar
Garces-Eisele, Javier Google Scholar
Gallagher, Robert Google Scholar
Niemeyer, Charlotte M. Google Scholar
Schrier, Stanley L. Google Scholar
Tallman, Martin Google Scholar
Grimwade, David Google Scholar
Ganser, Arnold Google Scholar
Berliner, Nancy Google Scholar
Ribeiro, Raul C. Google Scholar
Lo-Coco, Francesco Google Scholar
Loewenberg, Bob Google Scholar
Sanz, Miguel A. Google Scholar
Instituição Universidade de São Paulo (USP)
Dana Farber Canc Inst
Clin Ruiz Puebla
Hosp Salvador
Asociac Espanola Primera Socorros Mutuos
Hosp Univ Dr Jose E Gonzalez
Fundacao HEMOPE
Univ Fed Rio Grande do Sul
Univ Fed Parana
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Santa Casa Med Sch
Ctr Med Nacl Siglo XXI
Northwestern Univ
Albert Einstein Canc Ctr
Univ Med Ctr
Stanford Univ
Mem Sloan Kettering Canc Ctr
Kings Coll London Sch Med
Hannover Med Sch
Harvard Univ
St Jude Childrens Res Hosp
Univ Roma Tor Vergata
Santa Lucia Fdn
Erasmus MC
Valencia Univ Med Sch
Resumo Thanks to modern treatment with all-trans retinoic acid and chemotherapy, acute promyelocytic leukemia (APL) is now the most curable type of leukemia. However, this progress has not yielded equivalent benefit in developing countries. the International Consortium on Acute Promyelocytic Leukemia (IC-APL) was established to create a network of institutions in developing countries that would exchange experience and data and receive support from well-established US and European cooperative groups. the IC-APL formulated expeditious diagnostic, treatment, and supportive guidelines that were adapted to local circumstances. APL was chosen as a model disease because of the potential impact on improved diagnosis and treatment. the project included 4 national coordinators and reference laboratories, common clinical record forms, 5 subcommittees, and laboratory and data management training programs. in addition, participating institutions held regular virtual and face-to-face meetings. Complete hematological remission was achieved in 153/180 (85%) patients and 27 (15%) died during induction. After a median follow-up of 28 months, the 2-year cumulative incidence of relapse, overall survival (OS), and disease-free survival (DFS) were 4.5%, 80%, and 91%, respectively. the establishment of the IC-APL network resulted in a decrease of almost 50% in early mortality and an improvement in OS of almost 30% compared with historical controls, resulting in OS and DFS similar to those reported in developed countries.
Idioma Inglês
Financiador American Society of Hematology
Fondazione Umberto Veronesi
Roche Saudi Arabia
Fundacao de Apoio a Pesquisa do Estado de São Paulo
Fundacion Mexicana para la Salud
St. Jude Children's Research Hospital
Cephalon Europe
Número do financiamento Fundacao de Apoio a Pesquisa do Estado de São Paulo: 1998/14247-6
Data 2013-03-14
Publicado em Blood. Washington: Amer Soc Hematology, v. 121, n. 11, p. 1935-1943, 2013.
ISSN 0006-4971 (Sherpa/Romeo, fator de impacto)
Editor Amer Soc Hematology
Extensão 1935-1943
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000321756700009

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