Structural and Photophysical Properties of Peptide Micro/Nanotubes Functionalized with Hypericin

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dc.contributor.author Souza, Marcia I.
dc.contributor.author Jaques, Ygor M.
dc.contributor.author Andrade, Gislaine P. de
dc.contributor.author Ribeiro, Anderson O.
dc.contributor.author Silva, Emerson R. da
dc.contributor.author Fileti, Eudes E. [UNIFESP]
dc.contributor.author Avilla, Erick de Souza
dc.contributor.author Pinheiro, Mauricio V. B.
dc.contributor.author Krambrock, Klaus
dc.contributor.author Alves, Wendel A.
dc.date.accessioned 2016-01-24T14:31:24Z
dc.date.available 2016-01-24T14:31:24Z
dc.date.issued 2013-03-07
dc.identifier http://dx.doi.org/10.1021/jp3113655
dc.identifier.citation Journal of Physical Chemistry B. Washington: Amer Chemical Soc, v. 117, n. 9, p. 2605-2614, 2013.
dc.identifier.issn 1520-6106
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36082
dc.description.abstract Hypericin is a photosensitizer with promising applications in photodynamic therapy (PDT) for cancer and infectious diseases treatments. Herein, we present a basic research study of L-diphenylalanine micro/nanotubes (FF-NTs) functionalized with hypericin. the system has special properties according to the hypericin concentration, with direct consequences on both morphological and photophysical behaviors. A clear dependence between the size of the tubes and the concentration of hypericin is revealed. the generation of reactive oxygen species (ROS) is found to be improved by similar to 57% in the presence of FF-NTs, as indirectly measured from the absorbance profile of 1,3-diphenylisobenzofuran (DPBF). in addition, when hypericin appears conjugated with FF-NTs, the characteristic fluorescence lifetime is significantly boosted, demonstrating the role of FF-NTs to enhance the photophysical properties and stabilizing the fluorophore in excited states. Electron paramagnetic resonance allows the proposition of a mechanism for the generation of ROS. Molecular dynamics simulations bring new insights into the interaction between hypericin and peptide assemblies, suggesting the spatial organization of the fluorophore onto the surface of the supramolecular structures as a key element to improve the photophysical properties reported here. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 2605-2614
dc.language.iso eng
dc.publisher Amer Chemical Soc
dc.relation.ispartof Journal of Physical Chemistry B
dc.rights Acesso restrito
dc.title Structural and Photophysical Properties of Peptide Micro/Nanotubes Functionalized with Hypericin en
dc.type Artigo
dc.contributor.institution Universidade Federal do ABC (UFABC)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal de Minas Gerais (UFMG)
dc.description.affiliation Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliation Univ Fed Minas Gerais, ICEx, Dept Fis, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipID FAPESP: 08/53576-9
dc.description.sponsorshipID FAPEMIG: APQ 02000-10
dc.description.sponsorshipID FAPESP: 08/57805-2
dc.description.sponsorshipID CNPq: 573672/2008-3
dc.description.sponsorshipID CNPq: 472197/2012-6
dc.identifier.doi 10.1021/jp3113655
dc.description.source Web of Science
dc.identifier.wos WOS:000315979600002



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