Prospective surveillance study of acute respiratory infections, influenza-like illness and seasonal influenza vaccine in a cohort of juvenile idiopathic arthritis patients

Prospective surveillance study of acute respiratory infections, influenza-like illness and seasonal influenza vaccine in a cohort of juvenile idiopathic arthritis patients

Author Carvalho, Luciana M. Google Scholar
Paula, Flavia E. de Google Scholar
Silvestre, Rodrigo V. D. Google Scholar
Roberti, Luciana R. Google Scholar
Arruda, Eurico Google Scholar
Mello, Wyller A. Google Scholar
Ferriani, Virginia Paes Leme Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
WHO Natl Influenza Ctr
Abstract Background: Acute respiratory infections (ARI) are frequent in children and complications can occur in patients with chronic diseases. We evaluated the frequency and impact of ARI and influenza-like illness (ILI) episodes on disease activity, and the immunogenicity and safety of influenza vaccine in a cohort of juvenile idiopathic arthritis (JIA) patients.Methods: Surveillance of respiratory viruses was conducted in JIA patients during ARI season (March to August) in two consecutive years: 2007 (61 patients) and 2008 (63 patients). Patients with ARI or ILI had respiratory samples collected for virus detection by real time PCR. in 2008, 44 patients were immunized with influenza vaccine. JIA activity index (ACRPed30) was assessed during both surveillance periods. Influenza hemagglutination inhibition antibody titers were measured before and 30-40 days after vaccination.Results: During the study period 105 ARI episodes were reported and 26.6% of them were ILI. of 33 samples collected, 60% were positive for at least one virus. Influenza and rhinovirus were the most frequently detected, in 30% of the samples. of the 50 JIA flares observed, 20% were temporally associated to ARI. Influenza seroprotection rates were higher than 70% (91-100%) for all strains, and seroconversion rates exceeded 40% (74-93%). in general, response to influenza vaccine was not influenced by therapy or disease activity, but patients using anti-TNF alpha drugs presented lower seroconversion to H1N1 strain. No significant differences were found in ACRPed30 after vaccination and no patient reported ILI for 6 months after vaccination.Conclusion: ARI episodes are relatively frequent in JIA patients and may have a role triggering JIA flares. Trivalent split influenza vaccine seems to be immunogenic and safe in JIA patients.
Keywords Acute respiratory infections
Respiratory viruses
Influenza-like illness
Influenza vaccine
Juvenile idiopathic arthritis
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundacao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo
Grant number CNPq: CNPQ 308101/2003
CAPES: CAPES 56/2007-5
Fundacao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo: FAEPA 2534/2008
Date 2013-03-07
Published in Pediatric Rheumatology. London: Biomed Central Ltd, v. 11, 10 p., 2013.
ISSN 1546-0096 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 10
Origin http://dx.doi.org/10.1186/1546-0096-11-10
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316352300001
URI http://repositorio.unifesp.br/handle/11600/36081

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