Grooming analysis algorithm: Use in the relationship between sleep deprivation and anxiety-like behavior

Grooming analysis algorithm: Use in the relationship between sleep deprivation and anxiety-like behavior

Autor Pires, Gabriel N. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Increased anxiety is a classic effect of sleep deprivation. However, results regarding sleep deprivation-induced anxiety-like behavior are contradictory in rodent models. the grooming analysis algorithm is a method developed to examine anxiety-like behavior and stress in rodents, based on grooming characteristics and microstructure. This study evaluated the applicability of the grooming analysis algorithm to distinguish sleep-deprived and control rats in comparison to traditional grooming analysis. Forty-six animals were distributed into three groups: control (n=22), paradoxical sleep-deprived (96 h, n=10) and total sleep deprived (6 h, n=14). Immediately after the sleep deprivation protocol, grooming was evaluated using both the grooming analysis algorithm and traditional measures (grooming latency, frequency and duration). Results showed that both paradoxical sleep-deprived and total sleep-deprived groups displayed grooming in a fragmented framework when compared to control animals. Variables from the grooming analysis algorithm were successful in distinguishing sleep-deprived and normal sleep animals regarding anxiety-like behavior. the grooming analysis algorithm and traditional measures were strongly correlated. in conclusion, the grooming analysis algorithm is a reliable method to assess the relationship between anxiety-like behavior and sleep deprivation. (C) 2012 Elsevier Inc. All rights reserved.
Palavra-chave Anxiety
Behavior
Grooming
Sleep
Sleep deprivation
Idioma Inglês
Financiador AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 2010/14768-0
FAPESP: 98/14303-0
Data de publicação 2013-03-05
Publicado em Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 41, p. 6-10, 2013.
ISSN 0278-5846 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 6-10
Fonte http://dx.doi.org/10.1016/j.pnpbp.2012.11.006
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000315324600002
Endereço permanente http://repositorio.unifesp.br/handle/11600/36079

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta