Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats

Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats

Author Rodrigues, Natalia Camargo Google Scholar
Brunelli, Roberta Google Scholar
Selistre de Araujo, Heloisa Sobreiro Google Scholar
Parizotto, Nivaldo Antonio Google Scholar
Renno, Ana Claudia Muniz Autor UNIFESP Google Scholar
Institution Universidade Federal de São Carlos (UFSCar)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: the effects of LLLT were studied during muscle regeneration through gene expression.Methods: It was evaluated 10 and 50 J/cm(2) doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression.Results: Irradiated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm(2). the MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm(2) after 21 days.Conclusion: These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Low-level laser therapy
Rat
Muscle repair
Genes expression
MRFs
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-03-05
Published in Journal of Photochemistry and Photobiology B-biology. Lausanne: Elsevier Science Sa, v. 120, p. 29-35, 2013.
ISSN 1011-1344 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 29-35
Origin https://dx.doi.org/10.1016/j.jphotobiol.2013.01.002
Access rights Closed access
Type Article
Web of Science ID WOS:000317882100004
URI https://repositorio.unifesp.br/handle/11600/36077

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