Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

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dc.contributor.author Almeida, Valéria de [UNIFESP]
dc.contributor.author Levin, Raquel [UNIFESP]
dc.contributor.author Peres, Fernanda Fiel [UNIFESP]
dc.contributor.author Niigaki, Suzy Tamie [UNIFESP]
dc.contributor.author Calzavara, Mariana Bendlin [UNIFESP]
dc.contributor.author Zuardi, Antonio Waldo
dc.contributor.author Hallak, Jaime Eduardo Cecilio
dc.contributor.author Crippa, José Alexandre de Souza
dc.contributor.author Abílio, Vanessa Costhek [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:23Z
dc.date.available 2016-01-24T14:31:23Z
dc.date.issued 2013-03-05
dc.identifier http://dx.doi.org/10.1016/j.pnpbp.2012.10.024
dc.identifier.citation Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 41, p. 30-35, 2013.
dc.identifier.issn 0278-5846
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36076
dc.description.abstract Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. in addition, SHRs present a hyperlocomotion that is reverted by typical and atypical antipsychotics, suggesting that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia as well as the effects of potential antipsychotics drugs. At the same time, an increase in social interaction in control animals similar to that induced by benzodiazepines is used to screen potential anxiolytic drugs. the aim of this study was to investigate the effects of CBD on social interaction presented by control animals (Wistar) and SHRs. the lowest dose of CBD (1 mg/kg) increased passive and total social interaction of Wistar rats. However, the hyperlocomotion and the deficit in social interaction displayed by SHRs were not altered by any dose of CBD. Our results do not support an antipsychotic property of cannabidiol on symptoms-like behaviors in SHRs but reinforce the anxiolytic profile of this compound in control rats. (C) 2012 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 30-35
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Progress in Neuro-psychopharmacology & Biological Psychiatry
dc.rights Acesso aberto
dc.subject Anxiety en
dc.subject Cannabidiol en
dc.subject Schizophrenia en
dc.subject SHR en
dc.subject Social interaction test en
dc.title Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Inst Nacl Ciencia & Tecnol Translac Med
dc.description.affiliation Universidade Federal de São Paulo, Dept Farmacol, UNIFESP, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Neurociencias & Ciencias Comportamento, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliation Inst Nacl Ciencia & Tecnol Translac Med, INCT TM, CNPq, Ribeirao Preto, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Farmacol, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: FAPESP - 2010/07994-3
dc.identifier.file WOS000315324600006.pdf
dc.identifier.doi 10.1016/j.pnpbp.2012.10.024
dc.description.source Web of Science
dc.identifier.wos WOS:000315324600006



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