Interleukin-6-174 G/C promoter gene polymorphism in nasal polyposis and asthma

Interleukin-6-174 G/C promoter gene polymorphism in nasal polyposis and asthma

Author Kosugi, Eduardo Macoto Autor UNIFESP Google Scholar
De Camargo-Kosugi, Cintia Meirelles Autor UNIFESP Google Scholar
Hirai, Elcio Roldan Autor UNIFESP Google Scholar
Mendes Neto, José Arruda Autor UNIFESP Google Scholar
Gregario, Luis Carlos Autor UNIFESP Google Scholar
Cotrim Guerreiro-Da-Silva, Ismael Dale Autor UNIFESP Google Scholar
Weckx, Luc Louis Maurice Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Interleukin-6 (IL-6) is an inflammatory mediator linked to nasal polyposis and asthma, with a single nucleotide polymorphism - 174 G/C that seems to promote an inflammatory status. We aimed to analyze the relationship between this polymorphism and asthmatic nasal polyposis patients.Methodology: Cross-sectional study to investigate IL-6 - 174 G/C genotypes of 45 nasal polyposis with asthma patients, 63 nasal polyposis-only patients, 45 asthma-only patients and 81 subjects without both diseases. Aspirin intolerance and atopy were main exclusion criteria. IL-6 genotyping was performed using the PCR method with specific primers followed by restriction enzyme analysis, classifying patients in GG, GC or CC genotype.Results: the GG genotype was the most frequent in all inflammatory groups. Less than 40% of controls presented with the GG genotype. There were significant differences between inflammatory groups and control group. No significant differences were seen when comparing inflammatory groups to each other, other than between nasal polyposis-only group and asthma-only group.Conclusion: the IL-6 74 GG genotype was found more frequently in all inflammatory groups than in controls. This genotype could influence nasal polyposis and asthma, and seems to be more important in the latter.
Keywords asthma
nasal polyps
genetic polymorphism
single nucleotide polymorphism
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-03-01
Published in Rhinology. Utrecht: Int Rhinologic Soc, v. 51, n. 1, p. 70-76, 2013.
ISSN 0300-0729 (Sherpa/Romeo, impact factor)
Publisher Int Rhinologic Soc
Extent 70-76
Access rights Closed access
Type Article
Web of Science ID WOS:000332267600011

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