The effects of bromocriptine on VEGF, kidney function and ovarian hyperstimulation syndrome in in vitro fertilization patients: a pilot study

The effects of bromocriptine on VEGF, kidney function and ovarian hyperstimulation syndrome in in vitro fertilization patients: a pilot study

Author Beltrame, Ana Lucia Google Scholar
Serafini, Paulo Google Scholar
Motta, Eduardo L. A. Autor UNIFESP Google Scholar
Soares Junior, Jose Maria Autor UNIFESP Google Scholar
Baracat, Edmund C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to evaluate the effects of bromocriptine on vascular endothelial growth factor (VEGF) levels in serum, kidney function and ovarian hyperstimulation syndrome in women undergoing in vitro fertilization. Twenty-eight women were randomly divided into two groups and were administered daily oral capsules for 14 days, starting on the day of human chorionic gonadotropin (hCG) administration. Group A received 2.0 mg of folic acid, whereas Group B was given 2.5 mg of bromocriptine. Physical exams, pelvic ultrasounds and laboratory evaluations were performed on the day of hCG administration and again 7 days later. No differences in ovarian hyperstimulation syndrome, urine volume, creatinine clearance, urine sodium concentration or serum VEGF levels were found between the two groups. Thus, these results indicate that bromocriptine does not affect blood levels of VEGF, kidney function or the incidence of ovarian hyperstimulation syndrome in high-risk patients subjected to in vitro fertilization.
Keywords Bromocriptine
fertilization
hyperstimulation syndrome
kidney function
VEGF
Language English
Date 2013-03-01
Published in Gynecological Endocrinology. New York: Informa Healthcare, v. 29, n. 3, p. 201-204, 2013.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 201-204
Origin http://dx.doi.org/10.3109/09513590.2012.736554
Access rights Closed access
Type Article
Web of Science ID WOS:000315166800004
URI http://repositorio.unifesp.br/handle/11600/36073

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