Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation

Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation

Author Amorim, Carlos E. N. Autor UNIFESP Google Scholar
Nogueira, Eliana Autor UNIFESP Google Scholar
Almeida, Sandro S. Autor UNIFESP Google Scholar
Gomes, Pedro P. G. Autor UNIFESP Google Scholar
Bacurau, Reury Frank Pereira Google Scholar
Suzete Ozaki, K. Autor UNIFESP Google Scholar
Cenedeze, Marcos A. Autor UNIFESP Google Scholar
Pacheco-Silva, Alvaro Autor UNIFESP Google Scholar
Câmara, Niels Olsen Saraiva Autor UNIFESP Google Scholar
Araujo, Ronaldo C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Hosp Israelita Albert Einstein
Abstract There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but few studies have investigated their importance after renal transplantation. the aim of this study was to investigate the clinical effects of the insertion/deletion polymorphism in the angiotensin I-converting enzyme (ACE) gene and the +9/-9 polymorphism in the kinin B2 receptor (B2R) gene in kidney-transplanted patients (n=215 ACE, n=203 B2R) compared with 443 healthy individuals. Demographic results showed that there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals. We also observed a higher frequency of these alleles in patients who had an elevated level of plasma creatinine. At day 7 post-transplantation, we found a higher prevalence of individuals with the DD genotype with elevated plasma creatinine level. Furthermore, individuals with the DD genotype had a higher chronic allograft dysfunction and graft loss compared with the II patient genotype, which showed no loss of graft. Taken together, our data suggest that the DD genotype is an indicator of an unfavorable prognosis following renal transplantation and could be related to kinin modulation.
Keywords angiotensin I-converting enzyme (ACE)
B2 receptor
renal transplantation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 12/02270-2
FAPESP: 2010/52180-4
Date 2013-03-01
Published in Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 394, n. 3, p. 369-377, 2013.
ISSN 1431-6730 (Sherpa/Romeo, impact factor)
Publisher Walter de Gruyter & Co
Extent 369-377
Origin http://dx.doi.org/10.1515/hsz-2012-0314
Access rights Closed access
Type Article
Web of Science ID WOS:000314757700008
URI http://repositorio.unifesp.br/handle/11600/36069

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account