Is the neck circumference an emergent predictor for inflammatory status in obese adults?

Is the neck circumference an emergent predictor for inflammatory status in obese adults?

Author Jamar, Giovana Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Belote, Carolina Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Furuya, Vicky Akemi Onizuca Autor UNIFESP Google Scholar
Carvalho-Ferreira, Joana Pereira de Autor UNIFESP Google Scholar
Andrade-Silva, Stephan Garcia Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Plasminogen Activator Inhibitor 1 (PAI-1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that associated with proinflammatory adipokines may increase the risk related to obesity. Anthropometric measures are commonly used in clinical practice and, currently, neck circumference (NC) has been used as a marker of cardiovascular risk that can favour inflammatory factors. Objective: To verify the possible correlations between prothrombotic and pro/anti-inflammatory markers with anthropometric measurements in obese. Subjects and methods: A total of 43 obese adults were enrolled. the variables include body mass, stature, body mass index (BMI), NC, chest circumference (CC), abdominal circumference (AC), hip circumference (HC), blood pressure and blood collection used to assess the level of adipokines. Results: the sample was stratified by BMI. PAI-1 levels were positively correlated with body mass (r=0.31, p=0.04), NC (r=0.43, p=0.004), CC (r=0.40, p=0.004), AC (r=0.37, p=0.01), diastolic blood pressure (r=0.35, p=0.03), leptin/adiponectin ratio (r=0.36, p=0.01) and negatively correlated with adiponectin (r=0.34, p=0.02). in stepwise multiple linear regression analysis, NC showed to be an independent predictor to PAI-1 when adjusted for gender and BMI, according to the age (=0.47, p=0.02 and =0.42, p=0.02 respectively). Conclusion: in conclusion, NC could be suggested as an independent predictor higher PAI-1. This association can be a new screening of persons at an enhanced cardiovascular risk and inflammation in this obese population, so useful in clinical practice.
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 11/51723-7
CNPq: 471108/2011-1
Date 2013-03-01
Published in International Journal of Clinical Practice. Hoboken: Wiley-Blackwell, v. 67, n. 3, p. 217-224, 2013.
ISSN 1368-5031 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 217-224
Access rights Closed access
Type Article
Web of Science ID WOS:000315117700007

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