Is the neck circumference an emergent predictor for inflammatory status in obese adults?

Is the neck circumference an emergent predictor for inflammatory status in obese adults?

Autor Jamar, G. Autor UNIFESP Google Scholar
Pisani, L. P. Autor UNIFESP Google Scholar
Oyama, L. M. Autor UNIFESP Google Scholar
Belote, C. Autor UNIFESP Google Scholar
Masquio, D. C. L. Autor UNIFESP Google Scholar
Furuya, V. A. Autor UNIFESP Google Scholar
Carvalho-Ferreira, J. P. Autor UNIFESP Google Scholar
Andrade-Silva, S. G. Autor UNIFESP Google Scholar
Damaso, A. R. Autor UNIFESP Google Scholar
Caranti, D. A. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Plasminogen Activator Inhibitor 1 (PAI-1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that associated with proinflammatory adipokines may increase the risk related to obesity. Anthropometric measures are commonly used in clinical practice and, currently, neck circumference (NC) has been used as a marker of cardiovascular risk that can favour inflammatory factors. Objective: To verify the possible correlations between prothrombotic and pro/anti-inflammatory markers with anthropometric measurements in obese. Subjects and methods: A total of 43 obese adults were enrolled. the variables include body mass, stature, body mass index (BMI), NC, chest circumference (CC), abdominal circumference (AC), hip circumference (HC), blood pressure and blood collection used to assess the level of adipokines. Results: the sample was stratified by BMI. PAI-1 levels were positively correlated with body mass (r=0.31, p=0.04), NC (r=0.43, p=0.004), CC (r=0.40, p=0.004), AC (r=0.37, p=0.01), diastolic blood pressure (r=0.35, p=0.03), leptin/adiponectin ratio (r=0.36, p=0.01) and negatively correlated with adiponectin (r=0.34, p=0.02). in stepwise multiple linear regression analysis, NC showed to be an independent predictor to PAI-1 when adjusted for gender and BMI, according to the age (=0.47, p=0.02 and =0.42, p=0.02 respectively). Conclusion: in conclusion, NC could be suggested as an independent predictor higher PAI-1. This association can be a new screening of persons at an enhanced cardiovascular risk and inflammation in this obese population, so useful in clinical practice.
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 11/51723-7
CNPq: 471108/2011-1
Data de publicação 2013-03-01
Publicado em International Journal of Clinical Practice. Hoboken: Wiley-Blackwell, v. 67, n. 3, p. 217-224, 2013.
ISSN 1368-5031 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 217-224
Fonte http://dx.doi.org/10.1111/ijcp.12041
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000315117700007
Endereço permanente http://repositorio.unifesp.br/handle/11600/36059

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